Linearity and stability of intravenous busulfan pharmacokinetics and the role of glutathione in busulfan elimination

Keyphrases

• Glutathione 100%
• Pharmacokinetics 100%
• Busulfan 100%
• Intravenous Busulfan 100%
• Pharmacokinetic Parameters 17%
• Fludarabine 17%
• Myeloablative Conditioning 17%
• Cumulative Dose 11%
• Plasma Concentration 11%
• Hematopoietic Stem Cell Transplantation 11%
• Reduced-intensity Conditioning 11%
• Dosing Protocol 11%
• Metabolism 5%
• Blood Samples 5%
• High Dose 5%
• Repeated Administration 5%
• Treatment Protocol 5%
• Daily Dose 5%
• Treatment Failure 5%
• Whole Blood 5%
• Treatment Cycle 5%
• Blood Concentration 5%
• First Cycle 5%
• Intra-subject Variability 5%
• Co-substrate 5%
• Systemic Exposure 5%
• Adjusted R2 5%
• Half-life Time 5%
• Conditioning Intensity 5%
• Concomitant Administration 5%
• Volume of Distribution 5%
• Cycle Dose 5%
• Mid-cycle 5%
• Compartmental Analysis 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Elimination 100%
• Pharmacokinetics 100%
• Glutathione 100%
• Busulfan 100%
• Pharmacokinetic Parameter 16%
• Fludarabine 16%
• Volume of Distribution 5%