LINAC radiosurgery in the management of parasagittal meningiomas

Uri Hadelsberg, Uzi Nissim, Zvi R. Cohen, Roberto Spiegelmann

Research output: Contribution to journalArticlepeer-review


Background: At present, there is no general agreement for the best approach to parasagittal meningiomas. Invasion of the superior sagittal sinus is frequent and responsible for relatively high recurrence rates following conventional microsurgery. Radiosurgery has the potential to treat less accessible portions of these tumors, and its application in this pathology is increasing either as a primary or a complementary therapeutic tool. Objective: To evaluate our results with LINAC radiosurgery for the treatment of parasagittal meningiomas. Methods: The patient cohort consisted of 74 patients treated for parasagittal meningioma by LINAC radiosurgery at our institution's Radiosurgery Unit during a 15-year period. Women accounted for 61% of patients. Thirteen patients (18%) underwent radiosurgery as the primary treatment for their meningioma. Results: The overall actuarial control rate was 90.6% at a mean follow-up of 49 months. In 17 patients (22.9%), there was no volumetric change. Fifty patients (67.5%) showed tumor shrinkage ranging from 15 to 80% of the original mass. In 7 patients, tumor recurrence was observed at an average time of 42.2 months after radiosurgery. All the patients with previously untreated tumors were controlled. Symptomatic transient peritumoral edema developed in 5 patients (6.7%) at a mean of 6.4 months after radiosurgery. Three patients complained of protracted headaches after treatment. Conclusions: LINAC radiosurgery was highly effective for the treatment of parasagittal meningiomas in this series. For small to medium-sized meningiomas with clear invasion of the sinusal lumen, radiosurgery is a reasonable option as a first-line treatment. Either alone or combined with conventional surgery, radiosurgery may improve the control rate for parasagittal meningiomas.

Original languageEnglish
Pages (from-to)10-16
Number of pages7
JournalStereotactic and Functional Neurosurgery
Issue number1
StatePublished - 6 Mar 2015
Externally publishedYes


  • LINAC radiosurgery
  • Meningioma, parasagittal
  • Radiation injury


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