Light-controlled collection-and-release of biomolecules by an on-chip nanostructured device

Vadim Krivitsky*, Ella Borberg, Marina Basovich, Omri Heifler, Fernando Patolsky

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We developed an on-chip selective protein separation and preconcentration platform for direct analysis of complex biosamples, using antibody~photoacid-modified Si nanopillars responsive to a light-controlled release of the tightly bound target proteins. This device is able to selectively collect and separate specific low abundant proteins, while easily removing unwanted blood components and desalting the sample, hence abrogating the need for sample preparation steps.

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages1684-1685
Number of pages2
ISBN (Electronic)9781733419000
StatePublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Country/TerritorySwitzerland
CityBasel
Period27/10/1931/10/19

Keywords

  • Biomolecules
  • Filtering
  • Light Control
  • Photoacid
  • Preconcentration
  • Silicon Nanopillars

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