Light and electron microscopic retinal findings in leigh’s disease

I. Kremer*, T. Lerman-Sagie, M. Mukamel, J. Sandbank, I. Nissenkom, M. Mimouni

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Funduscopic and retinal light- and electron-microscopic findings are described in an infant with progressive neurologic deterioration leading to death. Brain autopsy findings were consistent with Leigh’s disease. The retinal mitochondria showed marked degenerative changes, the cristae were almost completely destroyed and electron-dense material filled a major part of the cavity. These changes are typically described in the late stages of mitochondrial diseases but have not been described before in retinal mitochondria in a patient with Leigh’s disease.

Original languageEnglish
Pages (from-to)106-110
Number of pages5
Issue number2-3
StatePublished - 1989


  • Degenerated mitochondria
  • Epiretinal membrane
  • Large macrophages
  • Mitochondrial disorders


Dive into the research topics of 'Light and electron microscopic retinal findings in leigh’s disease'. Together they form a unique fingerprint.

Cite this