Light activation of dopaminergic neurons in rat retina is mediated through photoreceptors

Y. Frucht; J. Vidauri; E. Melamed

doi:10.1016/0006-8993(82)90180-9

Light activation of dopaminergic neurons in rat retina is mediated through photoreceptors

Y. Frucht, J. Vidauri, E. Melamed

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of light on retinal dopamine turnover was studied in the RCS mutant strain of rats with inherited retinal dystrophy and in age-matched controls. Retinal dopamine and DOPAC were decreased in the 60-day-old RCS rats with complete photoreceptor degeneration killed in the light phase of the light-dark cycle. After 24 h dark adaptation, exposure to light markedly increased retinal DOPAC and dopamine in controls but had no effect in 70-day-old RCS dystrophic animals. Findings indicate that light activates retinal dopaminergic neurons via photoreceptor stimulation and not directly.

Original language	English
Pages (from-to)	153-156
Number of pages	4
Journal	Brain Research
Volume	249
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(82)90180-9
State	Published - 7 Oct 1982
Externally published	Yes

Keywords

DOPAC
RCS retinal dystrophy
dopamine
dopaminergic neurons
light activation
photoreceptor degeneration
retina

Access to Document

10.1016/0006-8993(82)90180-9

Cite this

@article{034bf40dd1294e338cb324d0a37616ab,

title = "Light activation of dopaminergic neurons in rat retina is mediated through photoreceptors",

abstract = "The effect of light on retinal dopamine turnover was studied in the RCS mutant strain of rats with inherited retinal dystrophy and in age-matched controls. Retinal dopamine and DOPAC were decreased in the 60-day-old RCS rats with complete photoreceptor degeneration killed in the light phase of the light-dark cycle. After 24 h dark adaptation, exposure to light markedly increased retinal DOPAC and dopamine in controls but had no effect in 70-day-old RCS dystrophic animals. Findings indicate that light activates retinal dopaminergic neurons via photoreceptor stimulation and not directly.",

keywords = "DOPAC, RCS retinal dystrophy, dopamine, dopaminergic neurons, light activation, photoreceptor degeneration, retina",

author = "Y. Frucht and J. Vidauri and E. Melamed",

note = "Funding Information: We thank Esther Friedlender, Yuta Rosenthal and Hadassah Gnesin for technical assistance, and Drs. Elaine Berman and Marsha Kaitz for supplying animals from their colony. This work was supported by the U.S.-Israel Binational Science Foundation (2348), the Chief Scientist's Office, Ministry of Health, Israel, and by a grant donated by the War-schaw Family in honor of Lawrence A. Harvey.",

year = "1982",

month = oct,

day = "7",

doi = "10.1016/0006-8993(82)90180-9",

language = "אנגלית",

volume = "249",

pages = "153--156",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Light activation of dopaminergic neurons in rat retina is mediated through photoreceptors

AU - Frucht, Y.

AU - Vidauri, J.

AU - Melamed, E.

N1 - Funding Information: We thank Esther Friedlender, Yuta Rosenthal and Hadassah Gnesin for technical assistance, and Drs. Elaine Berman and Marsha Kaitz for supplying animals from their colony. This work was supported by the U.S.-Israel Binational Science Foundation (2348), the Chief Scientist's Office, Ministry of Health, Israel, and by a grant donated by the War-schaw Family in honor of Lawrence A. Harvey.

PY - 1982/10/7

Y1 - 1982/10/7

N2 - The effect of light on retinal dopamine turnover was studied in the RCS mutant strain of rats with inherited retinal dystrophy and in age-matched controls. Retinal dopamine and DOPAC were decreased in the 60-day-old RCS rats with complete photoreceptor degeneration killed in the light phase of the light-dark cycle. After 24 h dark adaptation, exposure to light markedly increased retinal DOPAC and dopamine in controls but had no effect in 70-day-old RCS dystrophic animals. Findings indicate that light activates retinal dopaminergic neurons via photoreceptor stimulation and not directly.

AB - The effect of light on retinal dopamine turnover was studied in the RCS mutant strain of rats with inherited retinal dystrophy and in age-matched controls. Retinal dopamine and DOPAC were decreased in the 60-day-old RCS rats with complete photoreceptor degeneration killed in the light phase of the light-dark cycle. After 24 h dark adaptation, exposure to light markedly increased retinal DOPAC and dopamine in controls but had no effect in 70-day-old RCS dystrophic animals. Findings indicate that light activates retinal dopaminergic neurons via photoreceptor stimulation and not directly.

KW - DOPAC

KW - RCS retinal dystrophy

KW - dopamine

KW - dopaminergic neurons

KW - light activation

KW - photoreceptor degeneration

KW - retina

UR - http://www.scopus.com/inward/record.url?scp=0019984994&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(82)90180-9

DO - 10.1016/0006-8993(82)90180-9

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0019984994

VL - 249

SP - 153

EP - 156

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -

Light activation of dopaminergic neurons in rat retina is mediated through photoreceptors

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this