Light activation of dopaminergic neurons in rat retina is mediated through photoreceptors

Y. Frucht, J. Vidauri, E. Melamed

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of light on retinal dopamine turnover was studied in the RCS mutant strain of rats with inherited retinal dystrophy and in age-matched controls. Retinal dopamine and DOPAC were decreased in the 60-day-old RCS rats with complete photoreceptor degeneration killed in the light phase of the light-dark cycle. After 24 h dark adaptation, exposure to light markedly increased retinal DOPAC and dopamine in controls but had no effect in 70-day-old RCS dystrophic animals. Findings indicate that light activates retinal dopaminergic neurons via photoreceptor stimulation and not directly.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalBrain Research
Volume249
Issue number1
DOIs
StatePublished - 7 Oct 1982
Externally publishedYes

Keywords

  • DOPAC
  • RCS retinal dystrophy
  • dopamine
  • dopaminergic neurons
  • light activation
  • photoreceptor degeneration
  • retina

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