Lidocaine to Prevent Ventricular Fibrillation in Early Acute Myocardial Infarction

John S. Edelsberg; Warren H. Gullen; H. M. Dunn; A. A.J. Adgey; Paul Kuritzky; James A. Reiffel; Curt R. Freed; Daniel David; Elieser Kaplinsky; Rudolph W. Koster; Arend J. Dunning; Bernard Lown

doi:10.1056/NEJM198604243141713

Lidocaine to Prevent Ventricular Fibrillation in Early Acute Myocardial Infarction

John S. Edelsberg, Warren H. Gullen, H. M. Dunn, A. A.J. Adgey, Paul Kuritzky, James A. Reiffel, Curt R. Freed, Daniel David, Elieser Kaplinsky, Rudolph W. Koster, Arend J. Dunning, Bernard Lown

Research output: Contribution to journal › Letter › peer-review

Abstract

To the Editor: In the October 31 issue of the Journal, Koster and Dunning¹ describe their study of the prophylactic use of lidocaine in presumed cases of myocardial infarction. Unfortunately, certain caveats that should be considered in interpreting the results were not adequately addressed in the article. First, although the authors refer to the study as double blind, the control subjects did not receive an injection. Thus, one wonders how much of the apparent effectiveness of the lidocaine was attributable to a direct pharmacologic action and how much to a placebo effect (possibly mediated by a decrease in catecholamines….

Original language	English
Pages (from-to)	1116-1118
Number of pages	3
Journal	New England Journal of Medicine
Volume	314
Issue number	17
DOIs	https://doi.org/10.1056/NEJM198604243141713
State	Published - 24 Apr 1986

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abstract = "To the Editor: In the October 31 issue of the Journal, Koster and Dunning1 describe their study of the prophylactic use of lidocaine in presumed cases of myocardial infarction. Unfortunately, certain caveats that should be considered in interpreting the results were not adequately addressed in the article. First, although the authors refer to the study as double blind, the control subjects did not receive an injection. Thus, one wonders how much of the apparent effectiveness of the lidocaine was attributable to a direct pharmacologic action and how much to a placebo effect (possibly mediated by a decrease in catecholamines….",

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AU - Edelsberg, John S.

AU - Gullen, Warren H.

AU - Dunn, H. M.

AU - Adgey, A. A.J.

AU - Kuritzky, Paul

AU - Reiffel, James A.

AU - Freed, Curt R.

AU - David, Daniel

AU - Kaplinsky, Elieser

AU - Koster, Rudolph W.

AU - Dunning, Arend J.

AU - Lown, Bernard

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Lidocaine to Prevent Ventricular Fibrillation in Early Acute Myocardial Infarction

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