TY - JOUR
T1 - Lidocaine inhalation attenuates the circulatory response to laryngoscopy and endotracheal intubation
AU - Sklar, Ben Zion
AU - Lurie, Samuel
AU - Ezri, Tiberiu
AU - Krichelli, David
AU - Savir, Irena
AU - Soroker, David
PY - 1992
Y1 - 1992
N2 - Study Objective: To evaluate the effect of lidocaine inhalation on the circulatory response to direct laryngoscopy and endotracheal intubation. Design: Prospective, randomized study. Setting: Operating theater at a public hospital. Patients: Eighty patients (ASA physical status I and II ages 25 to 45 years) scheduled for major abdominal surgery. Interventions: In the first stage, 40 patients were randomly assigned to receive inhalation of either lidocaine 40 mg or a 0.9% solution of sodium chloride (placebo). In the second stage, the next 20 consecutive patients received inhalation of lidocaine 120 mg, and another 20 consecutive patients received intravenous (IV) lidocaine 1 mg/kg. Measurements and Main Results: Mean arterial pressure rose significantly in the IV lidocaine group (21.2 mmHg; p < 0.05), the saline inhalation group (29.2 mmHg; p < 0.05), and the lidocaine 40 mg inhalation group (22.9 mmHg; p < 0.05), but not in the lidocaine 120 mg inhalation group (10.1 mmHg). The heart rate (HR) response to intubation with lidocaine inhalation was dose dependent. In the saline inhalation group, HR increased by 15.6 beats per minute (bpm) (p < 0.05); in the lidocaine 40 mg inhalation group, HR increased by 9.1 bpm (p < 0.05); and in the lidocaine 120 mg inhalation group, HR increased by only 3.1 bpm. Conclusion: Inhalation of lidocaine 120 mg prior to induction of anesthesia is an effective, safe, and convenient method to attenuate the circulatory response to laryngoscopy and endotracheal intubation.
AB - Study Objective: To evaluate the effect of lidocaine inhalation on the circulatory response to direct laryngoscopy and endotracheal intubation. Design: Prospective, randomized study. Setting: Operating theater at a public hospital. Patients: Eighty patients (ASA physical status I and II ages 25 to 45 years) scheduled for major abdominal surgery. Interventions: In the first stage, 40 patients were randomly assigned to receive inhalation of either lidocaine 40 mg or a 0.9% solution of sodium chloride (placebo). In the second stage, the next 20 consecutive patients received inhalation of lidocaine 120 mg, and another 20 consecutive patients received intravenous (IV) lidocaine 1 mg/kg. Measurements and Main Results: Mean arterial pressure rose significantly in the IV lidocaine group (21.2 mmHg; p < 0.05), the saline inhalation group (29.2 mmHg; p < 0.05), and the lidocaine 40 mg inhalation group (22.9 mmHg; p < 0.05), but not in the lidocaine 120 mg inhalation group (10.1 mmHg). The heart rate (HR) response to intubation with lidocaine inhalation was dose dependent. In the saline inhalation group, HR increased by 15.6 beats per minute (bpm) (p < 0.05); in the lidocaine 40 mg inhalation group, HR increased by 9.1 bpm (p < 0.05); and in the lidocaine 120 mg inhalation group, HR increased by only 3.1 bpm. Conclusion: Inhalation of lidocaine 120 mg prior to induction of anesthesia is an effective, safe, and convenient method to attenuate the circulatory response to laryngoscopy and endotracheal intubation.
KW - Anesthesia, inhalation
KW - intubation, intratracheal
KW - laryngoscopy
KW - lidocaine, inhalation of
UR - http://www.scopus.com/inward/record.url?scp=0026803043&partnerID=8YFLogxK
U2 - 10.1016/0952-8180(92)90160-3
DO - 10.1016/0952-8180(92)90160-3
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AN - SCOPUS:0026803043
SN - 0952-8180
VL - 4
SP - 382
EP - 385
JO - Journal of Clinical Anesthesia
JF - Journal of Clinical Anesthesia
IS - 5
ER -