TY - JOUR
T1 - Level of glycemic control and pregnancy outcome in type 1 diabetes
T2 - a comparison between multiple daily insulin injections and continuous subcutaneous insulin infusions
AU - Chen, Rony
AU - Ben-Haroush, Avi
AU - Weissman-Brenner, Alina
AU - Melamed, Nir
AU - Hod, Moshe
AU - Yogev, Yariv
PY - 2007/10
Y1 - 2007/10
N2 - Objective: We aimed to compare glycemic control and pregnancy outcome in type I diabetic patients treated by 2 modes of treatment: multiple daily injections of insulin (MDI) and continuous subcutaneous insulin infusions (CSII). Study Design: In a retrospective, matched-control study, patients treated by MDI were compared with patients treated by CSII in a ratio of 2:1. Level of glycemic control and pregnancy outcome was compared. Results: Overall, 90 women were evaluated; of them 30 were treated by CSII and 60 by MDI. No between-group differences were found in maternal age, nulliparity rate, severity and duration of diabetes, prepregnancy body mass index, and weight gain during pregnancy. The rate of diabetic ketoacidosis (DKA) and neonatal hypoglycemia were significantly higher in the CSII group (13% vs 2%, P = .04) and (35% vs 13%, P = .01), respectively. No significant differences were found in pregnancy outcome measures. Conclusion: In type 1 diabetes, glycemic control and pregnancy outcome are compromised, regardless of treatment modality. CSII may be associated with higher rate of both maternal DKA and neonatal hypoglycemic events.
AB - Objective: We aimed to compare glycemic control and pregnancy outcome in type I diabetic patients treated by 2 modes of treatment: multiple daily injections of insulin (MDI) and continuous subcutaneous insulin infusions (CSII). Study Design: In a retrospective, matched-control study, patients treated by MDI were compared with patients treated by CSII in a ratio of 2:1. Level of glycemic control and pregnancy outcome was compared. Results: Overall, 90 women were evaluated; of them 30 were treated by CSII and 60 by MDI. No between-group differences were found in maternal age, nulliparity rate, severity and duration of diabetes, prepregnancy body mass index, and weight gain during pregnancy. The rate of diabetic ketoacidosis (DKA) and neonatal hypoglycemia were significantly higher in the CSII group (13% vs 2%, P = .04) and (35% vs 13%, P = .01), respectively. No significant differences were found in pregnancy outcome measures. Conclusion: In type 1 diabetes, glycemic control and pregnancy outcome are compromised, regardless of treatment modality. CSII may be associated with higher rate of both maternal DKA and neonatal hypoglycemic events.
KW - glycemic control
KW - insulin pump
KW - pregnancy
KW - type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=34848832937&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2007.06.007
DO - 10.1016/j.ajog.2007.06.007
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AN - SCOPUS:34848832937
SN - 0002-9378
VL - 197
SP - 404.e1-404.e5
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 4
ER -