Levamisole circumvents inhibition of lymphocyte activation imposed by uremic serum

D Modai; J Weissgarten; U Shaked; S Segal; A Pik; R Fuchs

doi:10.1159/000183515

Levamisole circumvents inhibition of lymphocyte activation imposed by uremic serum

D Modai, J Weissgarten, U Shaked, S Segal, A Pik, R Fuchs

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3 Scopus citations

Abstract

Uremic serum inhibits thymidine incorporation of phytohemagglutinin-stimulated lymphocytes originating in normal individuals. In this study the effect of levamisole on such inhibition was investigated. Preincubation with a wide range of levamisole concentrations resulted in complete prevention of the inhibitory effect imposed by uremic serum on thymidine incorporation. We would like to suggest that uremic serum possibly inhibits thymidine incorporation of normal lymphocytes by imposing an abnormal cyclic GMP/cyclic AMP intracellular ratio, and that levamisole may restore this ratio to normal.

Original language	English
Pages (from-to)	436-9
Number of pages	4
Journal	Nephron
Volume	40
Issue number	4
DOIs	https://doi.org/10.1159/000183515
State	Published - 1985

Keywords

Adolescent
Adult
Female
Humans
Levamisole/pharmacology
Lymphocyte Activation/drug effects
Male
Middle Aged
Phytohemagglutinins/pharmacology
Uremia/blood

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10.1159/000183515

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title = "Levamisole circumvents inhibition of lymphocyte activation imposed by uremic serum",

abstract = "Uremic serum inhibits thymidine incorporation of phytohemagglutinin-stimulated lymphocytes originating in normal individuals. In this study the effect of levamisole on such inhibition was investigated. Preincubation with a wide range of levamisole concentrations resulted in complete prevention of the inhibitory effect imposed by uremic serum on thymidine incorporation. We would like to suggest that uremic serum possibly inhibits thymidine incorporation of normal lymphocytes by imposing an abnormal cyclic GMP/cyclic AMP intracellular ratio, and that levamisole may restore this ratio to normal.",

keywords = "Adolescent, Adult, Female, Humans, Levamisole/pharmacology, Lymphocyte Activation/drug effects, Male, Middle Aged, Phytohemagglutinins/pharmacology, Uremia/blood",

author = "D Modai and J Weissgarten and U Shaked and S Segal and A Pik and R Fuchs",

year = "1985",

doi = "10.1159/000183515",

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T1 - Levamisole circumvents inhibition of lymphocyte activation imposed by uremic serum

AU - Modai, D

AU - Weissgarten, J

AU - Shaked, U

AU - Segal, S

AU - Pik, A

AU - Fuchs, R

PY - 1985

Y1 - 1985

N2 - Uremic serum inhibits thymidine incorporation of phytohemagglutinin-stimulated lymphocytes originating in normal individuals. In this study the effect of levamisole on such inhibition was investigated. Preincubation with a wide range of levamisole concentrations resulted in complete prevention of the inhibitory effect imposed by uremic serum on thymidine incorporation. We would like to suggest that uremic serum possibly inhibits thymidine incorporation of normal lymphocytes by imposing an abnormal cyclic GMP/cyclic AMP intracellular ratio, and that levamisole may restore this ratio to normal.

AB - Uremic serum inhibits thymidine incorporation of phytohemagglutinin-stimulated lymphocytes originating in normal individuals. In this study the effect of levamisole on such inhibition was investigated. Preincubation with a wide range of levamisole concentrations resulted in complete prevention of the inhibitory effect imposed by uremic serum on thymidine incorporation. We would like to suggest that uremic serum possibly inhibits thymidine incorporation of normal lymphocytes by imposing an abnormal cyclic GMP/cyclic AMP intracellular ratio, and that levamisole may restore this ratio to normal.

KW - Adolescent

KW - Adult

KW - Female

KW - Humans

KW - Levamisole/pharmacology

KW - Lymphocyte Activation/drug effects

KW - Male

KW - Middle Aged

KW - Phytohemagglutinins/pharmacology

KW - Uremia/blood

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SN - 1660-8151

VL - 40

SP - 436

EP - 439

JO - Nephron

JF - Nephron

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ER -

Levamisole circumvents inhibition of lymphocyte activation imposed by uremic serum

Abstract

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