Leukopenia: Idiopathic or Drug-Induced — How to Differentiate?

Y. Shoenfeld*

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review


To the Editor: In the case report presented in the letter by Gavras and Gavras (February 25 issue) a total white-cell count fluctuated spontaneously from 3200 to 7500 per cubic millimeter, making it difficult to differentiate between drug-induced or idiopathic leukopenia and normal variation.1 This kind of fluctuation is probably more common than is appreciated, since it has already been noted in normal subjects2 and in subjects with benign familial leukopenia.3 However, since most white-cell counts are performed in the morning or scheduled too infrequently to indicate changes that occur within a day, many of these fluctuations are missed.2 On.

Original languageEnglish
Pages (from-to)251
Number of pages1
JournalNew England Journal of Medicine
Issue number4
StatePublished - 22 Jul 1982
Externally publishedYes


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