Leukocyte alkaline phosphatase and carcinoembryonic antigen colorectal cancer patients (Usefulness in the assessment of the stage)

Natalia Walach, Amiram Guterman, Jacob L. Zaidman, Suzana Kaufman, Sally Scharf

Research output: Contribution to journalArticlepeer-review

Abstract

Leukocyte alkaline phosphatase (LAP) scores in peripheral blood, and plasma carcinoembryonic antigen (CEA) levels were determined in 122 colorectal cancer patients, and compared to 30 healthy persons. who served as controls. Both markers are gradually elevated according to the severity of tumor penetration. LAP scores in Dukes'C and D (157 ± 79) were significantly higher than in Dukes’A. B1 and B2 (81 ± 43), p<0.001. CEA levels were also higher in Dukes’C and D (50 ± 95) than in patients with Dukes’A, B1 and B2 (25 ± 54). p<0.07. but less significantly. The LAP score has at least the same reliability as the CEA values as a marker of stage in colorectal cancer patients.

Original languageEnglish
Pages (from-to)128-130
Number of pages3
JournalOncology
Volume48
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • Carcinoembryonic antigen
  • Colorectal cancer
  • Leukocyte alkaline phosphatase

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