Leukocyte Adhesion Deficiency Type III: Clinical Features and Treatment with Stem Cell Transplantation

Polina Y. Stepensky*, Baruch Wolach, Ronit Gavrieli, Sharon Rousso, Tal Ben Ami, Vladimir Goldman, Katya Rozovsky, Suhair Hanna, Amos Etzioni, Michael Weintraub

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Summary: Leukocyte adhesion deficiency type III (LADIII) is an autosomal recessive disorder that presents with a severe leukocyte adhesion defect and a Glanzmann-type thrombocytopathy. Hematopoietic stem cell transplantation (HSCT)-the only definitive treatment for LADIII-appears to have a high rate of complications. In this study, we describe a new group of patients with LADIII, highlighting further clinical and immunologic aspects of this disease, and reevaluating the effectiveness of HSCT for its treatment. The patients had clinical and laboratory findings consistent with LADIII. Molecular analysis confirmed the presence of a mutation in the kindlin-3 gene. HSCT was carried out in 3 patients and was successful in 2. The diagnosis of LADIII should be considered in all patients who present with recurrent infections and a bleeding diathesis, regardless of the leukocyte count. LADIII is a primary immune deficiency, which can be successfully corrected by bone marrow transplantation if applied early in the course of the disease using appropriate conditioning.

Original languageEnglish
Pages (from-to)264-268
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Volume37
Issue number4
DOIs
StatePublished - 1 Dec 2015
Externally publishedYes

Keywords

  • leukocyte adhesion deficiency
  • neutrophil functions
  • stem cell transplantation

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