Leukemia of early infancy: Early B‐cell lineage associated with t(4:11)

Batia Stark*, Tehila Umiel, Zipora Mammon, Naomi Galili, Meir Dzaledetti, Ian J. Cohen, Mina Steinberg, Ruth Vogel, Rina Zaizov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A case of infantile acute leukemia associated with translocation t(4:11)(q21:q23) is reported. This leukemia has a very poor prognosis, and this patient survived for only 9 months. The blast cell morphology was L1/L2 according to the FAB classification and showed a lymphoid appearance on transmission electron microscopy. The histochemical stains showed a pattern of periodic acid‐Schiff positivity and variable alpha‐naphtyl acetate staining. The cells were TdT‐positive and surface‐marker phenotyping was positive for Ia‐like and B4 antigens but negative for CALLA, T‐cell markers, myelocyte and monocyte markers. The leukemic cells represent a frozen state of a very early precursor, corresponding to the earliest recognizable stage of the B‐cell lineage. This observation may contribute to the controversion regarding the cell origin of this unique leukemia associated with t(4:11), lymphatic versus null cell, early myeloid, or mixed, and points to the possibility of a very early B‐cell lineage leukemia.

Original languageEnglish
Pages (from-to)1265-1271
Number of pages7
JournalCancer
Volume58
Issue number6
DOIs
StatePublished - 15 Sep 1986
Externally publishedYes

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