TY - JOUR
T1 - Leukemia of early infancy
T2 - Early B‐cell lineage associated with t(4:11)
AU - Stark, Batia
AU - Umiel, Tehila
AU - Mammon, Zipora
AU - Galili, Naomi
AU - Dzaledetti, Meir
AU - Cohen, Ian J.
AU - Steinberg, Mina
AU - Vogel, Ruth
AU - Zaizov, Rina
PY - 1986/9/15
Y1 - 1986/9/15
N2 - A case of infantile acute leukemia associated with translocation t(4:11)(q21:q23) is reported. This leukemia has a very poor prognosis, and this patient survived for only 9 months. The blast cell morphology was L1/L2 according to the FAB classification and showed a lymphoid appearance on transmission electron microscopy. The histochemical stains showed a pattern of periodic acid‐Schiff positivity and variable alpha‐naphtyl acetate staining. The cells were TdT‐positive and surface‐marker phenotyping was positive for Ia‐like and B4 antigens but negative for CALLA, T‐cell markers, myelocyte and monocyte markers. The leukemic cells represent a frozen state of a very early precursor, corresponding to the earliest recognizable stage of the B‐cell lineage. This observation may contribute to the controversion regarding the cell origin of this unique leukemia associated with t(4:11), lymphatic versus null cell, early myeloid, or mixed, and points to the possibility of a very early B‐cell lineage leukemia.
AB - A case of infantile acute leukemia associated with translocation t(4:11)(q21:q23) is reported. This leukemia has a very poor prognosis, and this patient survived for only 9 months. The blast cell morphology was L1/L2 according to the FAB classification and showed a lymphoid appearance on transmission electron microscopy. The histochemical stains showed a pattern of periodic acid‐Schiff positivity and variable alpha‐naphtyl acetate staining. The cells were TdT‐positive and surface‐marker phenotyping was positive for Ia‐like and B4 antigens but negative for CALLA, T‐cell markers, myelocyte and monocyte markers. The leukemic cells represent a frozen state of a very early precursor, corresponding to the earliest recognizable stage of the B‐cell lineage. This observation may contribute to the controversion regarding the cell origin of this unique leukemia associated with t(4:11), lymphatic versus null cell, early myeloid, or mixed, and points to the possibility of a very early B‐cell lineage leukemia.
UR - http://www.scopus.com/inward/record.url?scp=0022535447&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(19860915)58:6<1265::AID-CNCR2820580615>3.0.CO;2-6
DO - 10.1002/1097-0142(19860915)58:6<1265::AID-CNCR2820580615>3.0.CO;2-6
M3 - מאמר
AN - SCOPUS:0022535447
VL - 58
SP - 1265
EP - 1271
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 6
ER -
