Leukaemia - A developmental perspective

Shai Izraeli*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Leukaemia is characterized by the accumulation of malignant haematopoietic precursors. Recent studies have revealed that acquired alterations in genes that regulate normal haematopoiesis are frequently detected in leukaemia. The progression to leukaemia depends on additional mutations that promote the survival of developmentally arrested cells. This review describes three examples of this general paradigm of leukaemogenesis: RUNX1 abnormalities in acute leukaemias, GATA1 mutations in the leukaemias of Down syndrome, and SCL and LMO2 ectopic expression in T cell acute lymphoblastic leukaemia.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalBritish Journal of Haematology
Issue number1
StatePublished - Jul 2004


  • GATA1
  • Leukaemia
  • RUNX1
  • SCL
  • Trisomy 21


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