Letting go of O-glycans

Haddas Saad, Chaitanya Patel, Gerardo Z. Lederkremer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The generation of free N-glycans, or unconjugated oligosaccharides derived from N-linked glycoproteins, is well understood, but whether a similar fate awaits O-linked glycoprotein carbohydrates was unknown. Hirayama et al. now reveal, by using only mannose as an energy source, the generation of free O-glycans in Saccharomyces cerevisiae, in the lumen of a secretory compartment, possibly the vacuole. These findings uncover the presence of a possible regulated degradation pathway for O-mannosylated glycoproteins.

Original languageEnglish
Pages (from-to)15912-15913
Number of pages2
JournalJournal of Biological Chemistry
Issue number44
StatePublished - 1 Nov 2019


FundersFunder number
Israel Science Foundation1593/16


    Dive into the research topics of 'Letting go of O-glycans'. Together they form a unique fingerprint.

    Cite this