TY - JOUR
T1 - Letting go of O-glycans
AU - Saad, Haddas
AU - Patel, Chaitanya
AU - Lederkremer, Gerardo Z.
N1 - Publisher Copyright:
© 2019 Saad et al. Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - The generation of free N-glycans, or unconjugated oligosaccharides derived from N-linked glycoproteins, is well understood, but whether a similar fate awaits O-linked glycoprotein carbohydrates was unknown. Hirayama et al. now reveal, by using only mannose as an energy source, the generation of free O-glycans in Saccharomyces cerevisiae, in the lumen of a secretory compartment, possibly the vacuole. These findings uncover the presence of a possible regulated degradation pathway for O-mannosylated glycoproteins.
AB - The generation of free N-glycans, or unconjugated oligosaccharides derived from N-linked glycoproteins, is well understood, but whether a similar fate awaits O-linked glycoprotein carbohydrates was unknown. Hirayama et al. now reveal, by using only mannose as an energy source, the generation of free O-glycans in Saccharomyces cerevisiae, in the lumen of a secretory compartment, possibly the vacuole. These findings uncover the presence of a possible regulated degradation pathway for O-mannosylated glycoproteins.
UR - http://www.scopus.com/inward/record.url?scp=85074538004&partnerID=8YFLogxK
U2 - 10.1074/jbc.H119.011245
DO - 10.1074/jbc.H119.011245
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AN - SCOPUS:85074538004
SN - 0021-9258
VL - 294
SP - 15912
EP - 15913
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 44
ER -