Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1

Roi Gazit; Raizy Gruda; Moran Elboim; Tal I. Arnon; Gil Katz; Hagit Achdout; Jacob Hanna; Udi Qimron; Guy Landau; Evgenia Greenbaum; Zichria Zakay-Rones; Angel Porgador; Ofer Mandelboim

doi:10.1038/ni1322

Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1

Roi Gazit
, Raizy Gruda
, Moran Elboim
, Tal I. Arnon
, Gil Katz
, Hagit Achdout
, Jacob Hanna
, Udi Qimron
, Guy Landau
, Evgenia Greenbaum
, Zichria Zakay-Rones
, Angel Porgador
, Ofer Mandelboim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

478 Scopus citations

Abstract

The elimination of viruses and tumors by natural killer cells is mediated by specific natural killer cell receptors. To study the in vivo function of a principal activating natural killer cell receptor, NCR1 (NKp46 in humans), we replaced the gene encoding this receptor (Ncr1) with a green fluorescent protein reporter cassette. There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1^gfp/gfp mice, and influenza virus infection was lethal in both 129/Sv and C57BL/ 6 Ncr1^gfp/gfp mice. We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus.

Original language	English
Pages (from-to)	517-523
Number of pages	7
Journal	Nature Immunology
Volume	7
Issue number	5
DOIs	https://doi.org/10.1038/ni1322
State	Published - May 2006
Externally published	Yes

Funding

Funders	Funder number
Israel Ministry of Health
European Commission	LSHC-CT-2002-518178
United States-Israel Binational Science Foundation
Israel Science Foundation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/ni1322

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title = "Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1",

abstract = "The elimination of viruses and tumors by natural killer cells is mediated by specific natural killer cell receptors. To study the in vivo function of a principal activating natural killer cell receptor, NCR1 (NKp46 in humans), we replaced the gene encoding this receptor (Ncr1) with a green fluorescent protein reporter cassette. There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1gfp/gfp mice, and influenza virus infection was lethal in both 129/Sv and C57BL/ 6 Ncr1gfp/gfp mice. We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus.",

author = "Roi Gazit and Raizy Gruda and Moran Elboim and Arnon, \{Tal I.\} and Gil Katz and Hagit Achdout and Jacob Hanna and Udi Qimron and Guy Landau and Evgenia Greenbaum and Zichria Zakay-Rones and Angel Porgador and Ofer Mandelboim",

note = "Funding Information: Supported by the Israel Science Foundation (O.M.), the Binational Science Foundation (O.M.), the Israel Ministry of Health and the European Commission (LSHC-CT-2002-518178 to O.M.).",

year = "2006",

month = may,

doi = "10.1038/ni1322",

language = "אנגלית",

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AU - Gazit, Roi

AU - Gruda, Raizy

AU - Elboim, Moran

AU - Arnon, Tal I.

AU - Katz, Gil

AU - Achdout, Hagit

AU - Hanna, Jacob

AU - Qimron, Udi

AU - Landau, Guy

AU - Greenbaum, Evgenia

AU - Zakay-Rones, Zichria

AU - Porgador, Angel

AU - Mandelboim, Ofer

N1 - Funding Information: Supported by the Israel Science Foundation (O.M.), the Binational Science Foundation (O.M.), the Israel Ministry of Health and the European Commission (LSHC-CT-2002-518178 to O.M.).

PY - 2006/5

Y1 - 2006/5

N2 - The elimination of viruses and tumors by natural killer cells is mediated by specific natural killer cell receptors. To study the in vivo function of a principal activating natural killer cell receptor, NCR1 (NKp46 in humans), we replaced the gene encoding this receptor (Ncr1) with a green fluorescent protein reporter cassette. There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1gfp/gfp mice, and influenza virus infection was lethal in both 129/Sv and C57BL/ 6 Ncr1gfp/gfp mice. We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus.

AB - The elimination of viruses and tumors by natural killer cells is mediated by specific natural killer cell receptors. To study the in vivo function of a principal activating natural killer cell receptor, NCR1 (NKp46 in humans), we replaced the gene encoding this receptor (Ncr1) with a green fluorescent protein reporter cassette. There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1gfp/gfp mice, and influenza virus infection was lethal in both 129/Sv and C57BL/ 6 Ncr1gfp/gfp mice. We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus.

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EP - 523

JO - Nature Immunology

JF - Nature Immunology

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ER -

Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1

Abstract

Funding

UN SDGs

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