Leptin promotes lupus T-cell autoimmunity

Gil Amarilyo, Noriko Iikuni, Fu Dong Shi, Aijing Liu, Giuseppe Matarese, Antonio La Cava

Research output: Contribution to journalArticlepeer-review

Abstract

In systemic lupus erythematosus (SLE), the impairment in apoptosis can facilitate the initiation and maintenance of autoimmune responses to self antigens. Here we show that the adipocytokine leptin, which is abnormally elevated in SLE, promotes the survival and proliferation of autoreactive T-cells in mice with an autoreactive T-cell repertoire, including (NZB x NZW)F1 lupus-prone mice. This ability of leptin to promote lupus T-cell autoimmunity suggests the possibility of a therapeutic targeting of leptin in SLE.

Original languageEnglish
Pages (from-to)530-533
Number of pages4
JournalClinical Immunology
Volume149
Issue number3 PB
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • Apoptosis
  • Autoimmunity
  • Autoreactive T cells
  • Systemic lupus erythematosus

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