TY - JOUR
T1 - Leishmania tropica in children
T2 - A retrospective study
AU - Solomon, Michal
AU - Schwartz, Eli
AU - Pavlotsky, Felix
AU - Sakka, Nicole
AU - Barzilai, Aviv
AU - Greenberger, Shoshana
N1 - Funding Information:
Dr Greenberger is supported by Talpiot Medical Leadership Program, Chaim Sheba Medical Center .
PY - 2014/8
Y1 - 2014/8
N2 - Background Limited data are available regarding topical and systemic therapies for Leishmania tropica in children. Objective We sought to characterize the clinical presentation and evaluate the efficacy and safety of topical and systemic treatments in pediatric patients infected with L tropica. Methods A retrospective study was performed on 47 children with L tropica cutaneous leishmaniasis. Treatments included topical or systemic therapy with liposomal amphotericin B or pentavalent antimony. Results Seventy patients with L tropica cutaneous leishmaniasis were treated at our center between 2008 and 2012, of which 47 (67%) were children. The average age of the pediatric population was 8.8 years, and the face was the most common site of involvement (76%). The average number of lesions was 2.6. 24 children (51%) required systemic therapy. The patients were treated with 3 to 5 mg/kg/d of intravenous liposomal amphotericin B, and a response was observed in 83% of the patients within 3 months. Limitations This was a retrospective study. Conclusion The disease burden of L tropica in children is high, and because of facial involvement and a low response to topical therapies, systemic therapy is often required. In our experience, liposomal amphotericin B treatment in children is safe and effective and is required for a considerably shorter duration than treatment with pentavalent antimony.
AB - Background Limited data are available regarding topical and systemic therapies for Leishmania tropica in children. Objective We sought to characterize the clinical presentation and evaluate the efficacy and safety of topical and systemic treatments in pediatric patients infected with L tropica. Methods A retrospective study was performed on 47 children with L tropica cutaneous leishmaniasis. Treatments included topical or systemic therapy with liposomal amphotericin B or pentavalent antimony. Results Seventy patients with L tropica cutaneous leishmaniasis were treated at our center between 2008 and 2012, of which 47 (67%) were children. The average age of the pediatric population was 8.8 years, and the face was the most common site of involvement (76%). The average number of lesions was 2.6. 24 children (51%) required systemic therapy. The patients were treated with 3 to 5 mg/kg/d of intravenous liposomal amphotericin B, and a response was observed in 83% of the patients within 3 months. Limitations This was a retrospective study. Conclusion The disease burden of L tropica in children is high, and because of facial involvement and a low response to topical therapies, systemic therapy is often required. In our experience, liposomal amphotericin B treatment in children is safe and effective and is required for a considerably shorter duration than treatment with pentavalent antimony.
KW - Leishmania tropica
KW - children
KW - cryotherapy
KW - intralesional
KW - liposomal amphotericin B
KW - paromomycin ointment
KW - sodium stibogluconate
UR - http://www.scopus.com/inward/record.url?scp=84904724998&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2013.12.047
DO - 10.1016/j.jaad.2013.12.047
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C2 - 24775403
AN - SCOPUS:84904724998
SN - 0190-9622
VL - 71
SP - 271
EP - 277
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 2
ER -