Left-right asymmetry of visual evoked potentials in brain-damaged patients: A mathematical model and experimental results

Shimon Abboud*, Leah Bar, Moshe Rosenfeld, Haim Ring, Itzhak Glass

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The left-right asymmetry in the potential amplitude on the scalp was studied in poststroke patients by using flash visual evoked potential (VEP) and a numerical two-dimensional model of the head. The left-right asymmetry of the VEP was measured in three patients after thrombosis, in one after hemorrhage, and in one healthy subject. The numerical model used computed tomography images to define the different comparttential distribution created by a dipole source in the occipital region was solved numerically with use of a finite volume method. Left-right asymmetry was calculated with serveral values of conductivity of the damaged region. The experimental results revealed a negative asymmetry in the three patients after thrombosis (i. e., the potential amplitude over the ischemic hemisphere was smaller than that over the intact hemisphere), whereas, in the patient after hemorrhage, a positive asymmetry was found. Nonsignificant left-right asymmetry was found in the healthy subject. The numerical model revealed that the electrical conductivity of the damaged tissue has a major effect on the left-right asymmetry. Negative asymmetry, such as that found for patients after thrombosis, was obtained when the conductivity of the damaged region was greater than that of the brain, whereas positive asymmetry (hemorrhage patient) was obtained when that conductivity was smaller than that of the brain. This finding indicates that the left-right asymmetry in the scalp VEP of patients after brain damage may be a result of changes in the conductivity of the volume conductor (the ischemic region) between the source and the electrodes.

Original languageEnglish
Pages (from-to)75-86
Number of pages12
JournalAnnals of Biomedical Engineering
Issue number1 Supplement
StatePublished - Sep 1995


  • Head model
  • Left-Right asymmetry
  • Visual evoked potentials


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