Left atrial size predicts long-term outcome after balloon mitral valvuloplasty

Michal Canetti, Rafael Kuperstein, Ido Cohen, Shir Raibman-Spector, Elad Maor, Ilan Hai, Israel M. Barbash, Ehud Regev, Adi Butnaru, Amit Segev, Victor Guetta, Paul Fefer

Research output: Contribution to journalArticlepeer-review


BACKGROUND: The treatment of choice for severe rheumatic mitral stenosis is balloon mitral valvuloplasty (BMV). Numerous predictors of immediate and long-term procedural success have been described. The aims of this study were to describe our experience with BMV over the last decade and to evaluate predictors of long-term event-free survival. METHODS: Medical records were retrospectively analyzed of patients who underwent BMV between 2009 and 2021. The primary outcome was a composite endpoint of all-cause mortality, mitral valve replacement (MVR), and repeat BMV. Long-term event-free survival was estimated using Kaplan-Meier curves. Logistic regression was used to create a multivariate model to assess pre-procedural predictors of the primary outcome. RESULTS: A total of 96 patients underwent BMV during the study period. The primary outcome occurred in 36 patients during 12-year follow-up: one (1%) patient underwent re-BMV, 28 (29%) underwent MVR, and eight (8%) died. Overall, event-free survival was 62% at 12 years. On multivariate analysis, pre-procedural left atrial volume index (LAVI) > 80 mL/m2 had a significant independent influence on event-free survival, as did previous mitral valve procedure and systolic pulmonary arterial pressure above 50 mmHg. CONCLUSIONS: Despite being a relatively low-volume center, excellent short and long-term results were demonstrated, with event-free survival rates consistent with previous studies from high-volume centers. LAVI independently predicted long-term event-free survival.

Original languageEnglish
Pages (from-to)753-761
Number of pages9
JournalCardiology Journal
Issue number5
StatePublished - 2023


  • balloon mitral valvuloplasty
  • event-free survival
  • left atrial size
  • mitral stenosis
  • mitral valve


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