LDH isoenzymes in cerebrospinal fluid in various brain tumours

Y. Lampl, Y. Paniri, Y. Eshel, I. Sarova-Pinhas

Research output: Contribution to journalArticlepeer-review


This study examined the isoenzymatic pattern of LDH in the cerebrospinal fluid (CSF) as well as the ratio between the five fractions of LDH among patients with various brain tumours, carcinomatous meningitis and control groups. LDH 1/LDH 2 <1 was found significant for carcinomatous meningitis (p < 0.001) and brain metastases (p < 0.001). LDH 1/LDH 2 ratio was found to be significantly lower in carcinomatous meningitis than in brain metastases (p < 0.05). No LDH 1/LDH 2 ratios smaller than 1 were found in the other groups. The LDH 1/LDH 2 ratio smaller than 1 was found in the early stage of carcinomatous meningitis without other evidences of the involvement of the leptomeninges. Examination of LDH 1/LDH 2 can be found as an adjunctive method to identify brain metastases and carcinomatous meningitis at the initial stage.

Original languageEnglish
Pages (from-to)697-699
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number8
StatePublished - 1990
Externally publishedYes


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