TY - JOUR
T1 - Latent inhibition effects reflected in event-related brain potentials in healthy controls and schizophrenics
AU - Guterman, Yossi
AU - Josiassen, Richard C.
AU - Bashore, Theodore E.
AU - Johnson, Michele
AU - Lubow, Robert E.
N1 - Funding Information:
The authors wish to thank Brian Foote, Jacques Martinerie and Joe Waldron for software development, as well as Mike Anderson and Steve Slepner for their technical assistance. Special thanks to Gabriele Gratton for providing us with eye movement correction software. This research was supported by a Fulbright Scholar Award from the US-Israel Educational Foundation to Y.G. and NIMH Grant MH42769 awarded to R.C.J. The research was accomplished during Y.G.'s stay as a post-doctoral fellow at the Medical College of Pennsylvania.
PY - 1996/7/5
Y1 - 1996/7/5
N2 - The present study examined the effects of pre-exposure of an irrelevant stimulus on reaction time and the contingent negative variation (CNV) in healthy controls and schizophrenic patients. In Phase I, subjects were either pre-exposed (PE) or not pre-exposed (NPE) to repeated presentations of an auditory probe stimulus (white noise), while engaged in counting auditory nonsense syllables. In Phase II, all subjects were required to produce a rapid motor response to a visual imperative stimulus that was preceded by the previously irrelevant auditory stimulus. During Phase II in controls, for PE as compared to NPE subjects, the build-up of CNV across trials was delayed. In schizophrenics, for both PE and NPE subjects, there was no pre-exposure effect on the CNV component. These findings indicate that ERPs may be useful in explicating the normal latent inhibition effect (poor associative learning to a stimulus after it has been passively pre-exposed) and its disruption in schizophrenia.
AB - The present study examined the effects of pre-exposure of an irrelevant stimulus on reaction time and the contingent negative variation (CNV) in healthy controls and schizophrenic patients. In Phase I, subjects were either pre-exposed (PE) or not pre-exposed (NPE) to repeated presentations of an auditory probe stimulus (white noise), while engaged in counting auditory nonsense syllables. In Phase II, all subjects were required to produce a rapid motor response to a visual imperative stimulus that was preceded by the previously irrelevant auditory stimulus. During Phase II in controls, for PE as compared to NPE subjects, the build-up of CNV across trials was delayed. In schizophrenics, for both PE and NPE subjects, there was no pre-exposure effect on the CNV component. These findings indicate that ERPs may be useful in explicating the normal latent inhibition effect (poor associative learning to a stimulus after it has been passively pre-exposed) and its disruption in schizophrenia.
KW - Contingent negative variation (CNV)
KW - Event-related brain potential (ERP)
KW - Latent inhibition
KW - Pre-exposure schizophrenia
KW - Reaction time
UR - http://www.scopus.com/inward/record.url?scp=0030570553&partnerID=8YFLogxK
U2 - 10.1016/0920-9964(95)00086-0
DO - 10.1016/0920-9964(95)00086-0
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AN - SCOPUS:0030570553
SN - 0920-9964
VL - 20
SP - 315
EP - 326
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 3
ER -