Latent inhibition effects reflected in event-related brain potentials in healthy controls and schizophrenics

Yossi Guterman*, Richard C. Josiassen, Theodore E. Bashore, Michele Johnson, Robert E. Lubow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The present study examined the effects of pre-exposure of an irrelevant stimulus on reaction time and the contingent negative variation (CNV) in healthy controls and schizophrenic patients. In Phase I, subjects were either pre-exposed (PE) or not pre-exposed (NPE) to repeated presentations of an auditory probe stimulus (white noise), while engaged in counting auditory nonsense syllables. In Phase II, all subjects were required to produce a rapid motor response to a visual imperative stimulus that was preceded by the previously irrelevant auditory stimulus. During Phase II in controls, for PE as compared to NPE subjects, the build-up of CNV across trials was delayed. In schizophrenics, for both PE and NPE subjects, there was no pre-exposure effect on the CNV component. These findings indicate that ERPs may be useful in explicating the normal latent inhibition effect (poor associative learning to a stimulus after it has been passively pre-exposed) and its disruption in schizophrenia.

Original languageEnglish
Pages (from-to)315-326
Number of pages12
JournalSchizophrenia Research
Volume20
Issue number3
DOIs
StatePublished - 5 Jul 1996

Keywords

  • Contingent negative variation (CNV)
  • Event-related brain potential (ERP)
  • Latent inhibition
  • Pre-exposure schizophrenia
  • Reaction time

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