TY - JOUR
T1 - Late-life depression as a risk factor for dementia
AU - Halperin, Ilan
AU - Korczyn, Amos D.
PY - 2007/3
Y1 - 2007/3
N2 - Cognitive dysfunction accompanying depression has been considered to be separate from dementia and, thus, has been termed pseudodementia, with the presumption that it will disappear once the depressed mood remits. On the other hand, depression accompanied by dementia fulfills the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition definition of mood disorder due to its general condition. However, lately it has been documented that depression may precede dementia and, in particular, Alzheimer's disease. Dementia and depression display many common biological features, such as white matter changes in the brain, reduction of hippocampal volume, changes in the serotonergic and noradrenergic systems and abnormalities in the hypothalamic-pituitary-adrenal axis. These changes point to extensive system damage, beginning with dysthymia and depression episodes, which, over the years, lead to the development of dementia, possibly through hypersecretion of corticosteroids that may be toxic to the hippocampus.
AB - Cognitive dysfunction accompanying depression has been considered to be separate from dementia and, thus, has been termed pseudodementia, with the presumption that it will disappear once the depressed mood remits. On the other hand, depression accompanied by dementia fulfills the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition definition of mood disorder due to its general condition. However, lately it has been documented that depression may precede dementia and, in particular, Alzheimer's disease. Dementia and depression display many common biological features, such as white matter changes in the brain, reduction of hippocampal volume, changes in the serotonergic and noradrenergic systems and abnormalities in the hypothalamic-pituitary-adrenal axis. These changes point to extensive system damage, beginning with dysthymia and depression episodes, which, over the years, lead to the development of dementia, possibly through hypersecretion of corticosteroids that may be toxic to the hippocampus.
KW - Alzheimer's disease
KW - Cortisol
KW - Dementia
KW - Depression
KW - Hippocampus
KW - Memory
KW - Noradrenaline
KW - Serotonin
KW - White matter changes
UR - http://www.scopus.com/inward/record.url?scp=34249276063&partnerID=8YFLogxK
U2 - 10.2217/14796708.2.2.201
DO - 10.2217/14796708.2.2.201
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AN - SCOPUS:34249276063
SN - 1479-6708
VL - 2
SP - 201
EP - 208
JO - Future Neurology
JF - Future Neurology
IS - 2
ER -