Laser-induced retinal nerve fiber layer injury in the nonhuman primate

Harry Zwick*, Michael M.D. Belkin, Joseph A. Zuclich, David J. Lund, Steven T. Schuschereba, D. K. Scales

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

We have evaluated the acute effects of Argon laser injury to the retinal nerve fiber layer (NFL) in the non-human primate. Single Argon laser exposures of 150 millijoules were employed to induce retinal NFL injury. Retinal NFL injury is not acute; unlike its parallel in retinal disease it has two components that emanate from the acute retinal injury site. The ascending component is more visible, primarily because it is ascending toward the disk, representing ganglion cell axons cut off from their nutrient base, the ganglion cell body; the descending component may require up to 3 weeks to develop. Its characterization depends on the distribution of retinal NFL and the slower degeneration of the ganglion cell bodies. Fluorescein angiography suggest a retinal capillary loss that occurs in the capillary bed of the retinal NFL defect. It may reflect a reduced capillary vascular requirement of the NFL as well as a possible reduction of activity in the axonal transport mechanisms in the ascending NFL defect.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsBruce E. Stuck, Michael Belkin
Pages89-96
Number of pages8
StatePublished - 1996
Externally publishedYes
EventLaser-Inflicted Eye Injuries: Epidemiology, Prevention, and Treatment - San Jose, CA, USA
Duration: 29 Jan 199630 Jan 1996

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume2674
ISSN (Print)0277-786X

Conference

ConferenceLaser-Inflicted Eye Injuries: Epidemiology, Prevention, and Treatment
CitySan Jose, CA, USA
Period29/01/9630/01/96

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