TY - JOUR
T1 - Laser-induced hyperthermia for treatment of granulation tissue growth in rats
AU - Landsberg, Roee
AU - DeRowe, Ari
AU - Katzir, Abraham
AU - Shtabsky, Alexander
AU - Fliss, Dan M.
AU - Gil, Ziv
N1 - Funding Information:
We state that the authors do not have a financial interest in the subject under discussion. Supported in part by grants from the Israeli Society of Otolaryngology Head and Neck Surgery, the Binational Science Foundation (BSF) and the Israeli Science Foundation (ISF) to Ziv Gil. Supported by an intramural grant from the Tel Aviv Sourasky Medical Center, Tel Aviv, Israel to Ziv Gil.
PY - 2009/4
Y1 - 2009/4
N2 - Objective: We aimed to develop a new technique for treatment of granulation tissue (GT) growth using local hyperthermia. Methods: A temperature-controlled diode laser system was developed for induction of mild hyperthermia in real time. GT was generated by harvesting the skin over the gluteal fascia in rats. Histopathological analysis was used to estimate the effect of hyperthermia on the tissue. Results: In untreated rats, GT was detected within 3 days and reached maximal thickness after 12 days. Hyperthermia at 43°C and above significantly decreased GT thickness (n = 8 per group). Hyperthermia at 48°C for 3 minutes was the most efficient parameter for treatment of GT (51% reduction), with minimal (5%) muscle necrosis. Conclusions: Hyperthermia can significantly inhibit GT growth, with minimal damage to surrounding structures. Our findings suggest a possible role for hyperthermia as a therapeutic model against GT. Further research and long-term studies are needed to explore the utility of laser-induced hyperthermia for inhibition of GT growth.
AB - Objective: We aimed to develop a new technique for treatment of granulation tissue (GT) growth using local hyperthermia. Methods: A temperature-controlled diode laser system was developed for induction of mild hyperthermia in real time. GT was generated by harvesting the skin over the gluteal fascia in rats. Histopathological analysis was used to estimate the effect of hyperthermia on the tissue. Results: In untreated rats, GT was detected within 3 days and reached maximal thickness after 12 days. Hyperthermia at 43°C and above significantly decreased GT thickness (n = 8 per group). Hyperthermia at 48°C for 3 minutes was the most efficient parameter for treatment of GT (51% reduction), with minimal (5%) muscle necrosis. Conclusions: Hyperthermia can significantly inhibit GT growth, with minimal damage to surrounding structures. Our findings suggest a possible role for hyperthermia as a therapeutic model against GT. Further research and long-term studies are needed to explore the utility of laser-induced hyperthermia for inhibition of GT growth.
UR - http://www.scopus.com/inward/record.url?scp=62849115963&partnerID=8YFLogxK
U2 - 10.1016/j.otohns.2008.12.004
DO - 10.1016/j.otohns.2008.12.004
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:62849115963
SN - 0194-5998
VL - 140
SP - 480
EP - 486
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 4
ER -