TY - JOUR
T1 - Laryngeal Side Effects of Tyrosine Kinase Inhibitors
AU - Ovnat Tamir, Sharon
AU - Gershnabel Milk, Dafna
AU - Roth, Yehudah
AU - Cinamon, Udi
AU - Winder, Asher
AU - Brenner, Ronen
AU - Katz, Ariel
AU - Marom, Tal
N1 - Publisher Copyright:
© 2016 The Voice Foundation
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Objectives Tyrosine kinase inhibitors (TKIs) are common targeted drugs, used in the treatment of hematological and solid malignancies. These drugs present a multitude of potential adverse effects. Laryngeal manifestations, including laryngeal edema, secondary to TKIs treatment have not been well studied, despite their potential lethality. Methods This cross-sectional study included adult patients (>18 years) treated with TKIs who were followed in a secondary medical center and underwent a voluntary otolaryngological examination, which included laryngeal fiber-optic laryngoscopy (FOL). FOL was independently performed by two senior otolaryngologists, and results were recorded and evaluated by two grading systems, to assess the degree of laryngeal edema. In addition, medical files were reviewed, and data collected included past medical history, signs and symptoms, physical examination, laboratory results, treatment type, and duration. Results Sixteen patients, aged 68.2 ± 13.6 years, were examined during October 2014 to December 2014. Of them, three (19%) were males. Eleven (68%) patients presented with varying degrees of laryngeal edema. A significant correlation was found between gastroesophageal reflux symptoms and laryngeal edema (P = 0.02). TKI treatment was stopped in one patient, because of symptomatic laryngeal edema, which completely resolved within 2 weeks. Conclusions Laryngeal edema was common in our study group. This edema was most often not life threatening. Yet, because of the potential severity of this side effect, we propose a routine FOL examination of patients before commencing TKI treatment and a reevaluation performed during treatment.
AB - Objectives Tyrosine kinase inhibitors (TKIs) are common targeted drugs, used in the treatment of hematological and solid malignancies. These drugs present a multitude of potential adverse effects. Laryngeal manifestations, including laryngeal edema, secondary to TKIs treatment have not been well studied, despite their potential lethality. Methods This cross-sectional study included adult patients (>18 years) treated with TKIs who were followed in a secondary medical center and underwent a voluntary otolaryngological examination, which included laryngeal fiber-optic laryngoscopy (FOL). FOL was independently performed by two senior otolaryngologists, and results were recorded and evaluated by two grading systems, to assess the degree of laryngeal edema. In addition, medical files were reviewed, and data collected included past medical history, signs and symptoms, physical examination, laboratory results, treatment type, and duration. Results Sixteen patients, aged 68.2 ± 13.6 years, were examined during October 2014 to December 2014. Of them, three (19%) were males. Eleven (68%) patients presented with varying degrees of laryngeal edema. A significant correlation was found between gastroesophageal reflux symptoms and laryngeal edema (P = 0.02). TKI treatment was stopped in one patient, because of symptomatic laryngeal edema, which completely resolved within 2 weeks. Conclusions Laryngeal edema was common in our study group. This edema was most often not life threatening. Yet, because of the potential severity of this side effect, we propose a routine FOL examination of patients before commencing TKI treatment and a reevaluation performed during treatment.
KW - Edema
KW - Fiber-optic laryngoscopy
KW - Larynx
KW - Tyrosine kinase inhibitor
UR - http://www.scopus.com/inward/record.url?scp=84939839079&partnerID=8YFLogxK
U2 - 10.1016/j.jvoice.2015.07.006
DO - 10.1016/j.jvoice.2015.07.006
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C2 - 26272538
AN - SCOPUS:84939839079
SN - 0892-1997
VL - 30
SP - 606
EP - 610
JO - Journal of Voice
JF - Journal of Voice
IS - 5
ER -