TY - JOUR
T1 - Large helical conformational deviations from ideal B-DNA and prokaryotic regulatory sites
AU - Nussinov, Ruth
PY - 1985/7/21
Y1 - 1985/7/21
N2 - The variations in several double helical DNA angular parameters have been calculated along about 60 bacterial and phage sequences, each several hundreds nucleotides long. Regions of large geometric irregularities are found at, or in the vicinity of, regulatory protein recognition sites. Based on these extensive computations I suggest that these structurally "wrinkled" regions facilitate the first stage of the recognition process.
AB - The variations in several double helical DNA angular parameters have been calculated along about 60 bacterial and phage sequences, each several hundreds nucleotides long. Regions of large geometric irregularities are found at, or in the vicinity of, regulatory protein recognition sites. Based on these extensive computations I suggest that these structurally "wrinkled" regions facilitate the first stage of the recognition process.
UR - http://www.scopus.com/inward/record.url?scp=0021791134&partnerID=8YFLogxK
U2 - 10.1016/S0022-5193(85)80094-1
DO - 10.1016/S0022-5193(85)80094-1
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AN - SCOPUS:0021791134
SN - 0022-5193
VL - 115
SP - 179
EP - 189
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
IS - 2
ER -