Lamellar macular holes associated with end-stage exudative age-related macular degeneration

Ori Segal, Joseph R. Ferencz, Michael Mimouni, Ronit Nesher, Perri Cohen, Arie Y. Nemet

Research output: Contribution to journalArticlepeer-review


Background: Reports of lamellar macular holes (LMHs) with underlying age-related macular degeneration (AMD) are rare, and the specific definition, pathogenesis and surgical recommendations for this macular condition remain unclear. Objectives: To present a series of LMHs in eyes with underlying end-stage AMD, and describe optical coherence tomography (OCT) detection of associated morphologic abnormalities. Methods: We reviewed the files of consecutive patients diagnosed with LMH and underlying end-stage AMD between September 2007 and September 2011. Results: Sixteen eyes of 14 patients were included in this study. The average follow-up after the OCT-established diagnosis of LMH was 19.8 months (range 4–48). The average visual acuity (VA) at last follow-up visit was 20/400 (20/60– 20/1200). The best-corrected VA was stable in 10 eyes (62.5%) and deteriorated in 6 (37.5%). There was a statistically significant correlation between VA and minimal foveal thickness (r = -0.598, P = 0.014). Conclusions: In this series of LMHs with underlying AMD the OCT findings were intraretinal fluid, cystic spaces and window defect.

Original languageEnglish
Pages (from-to)750-754
Number of pages5
JournalIsrael Medical Association Journal
Issue number12
StatePublished - Dec 2015


  • Age-related macular degeneration (AMD)
  • End-stage AMD
  • Lamellar macular hole (LMH)
  • Optical coherence tomography (OCT)


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