Lagrangian methods for blood damage estimation in cardiovascular devices - How numerical implementation affects the results

Gil Marom, Danny Bluestein

Research output: Contribution to journalArticlepeer-review

Abstract

This paper evaluated the influence of various numerical implementation assumptions on predicting blood damage in cardiovascular devices using Lagrangian methods with Eulerian computational fluid dynamics. The implementation assumptions that were tested included various seeding patterns, stochastic walk model, and simplified trajectory calculations with pathlines. Post processing implementation options that were evaluated included single passage and repeated passages stress accumulation and time averaging. This study demonstrated that the implementation assumptions can significantly affect the resulting stress accumulation, i.e., the blood damage model predictions. Careful considerations should be taken in the use of Lagrangian models. Ultimately, the appropriate assumptions should be considered based the physics of the specific case and sensitivity analysis, similar to the ones presented here, should be employed.

Original languageEnglish
Pages (from-to)113-122
Number of pages10
JournalExpert Review of Medical Devices
Volume13
Issue number2
DOIs
StatePublished - 1 Feb 2016
Externally publishedYes

Keywords

  • Blood damage model
  • Lagrangian methods
  • cardiovascular devices
  • computational fluid dynamics
  • numerical modeling

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