Lactic dehydrogenase isoenzymes in cerebrospinal fluid of children with Guillain-Barré syndrome

M. Nussinovitch, D. Prais, Y. Finkelstein, D. Harel, J. Amir, B. Volovitz

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Increased levels of lactic dehydrogenase (LDH) in the cerebrospinal fluid (CSF) have been reported in association with several intracranial pathologies. No studies have been performed on patients with Guillain-Barré syndrome (GBS). Aims: To study LDH isoenzymes in CSF of children with GBS. Methods: CSF samples collected from nine patients with GBS were analysed for total LDH isoenzymes activity, and compared to samples from 15 patients with normal results. Results: Mean total LDH activity was 33.33 (6.63) U/l. All patients had significantly increased LDH-3 isoenzyme compared to controls. LDH-3 was the predominant fraction, accounting for more than 50% of total LDH activity and present in more than twice the percentage of LDH-1 or LDH-2. By contrast, in the control group, there were high percentages of mainly LDH-1 and LDH-2. Conclusions: GBS is apparently associated with a distinct LDH isoenzyme pattern in the CSF. More studies are needed to confirm the rise in LDH-3, as serial CSF analyses are unavailable, and to determine the optimum time of analysis when this finding first becomes detectable.

Original languageEnglish
Pages (from-to)255-256
Number of pages2
JournalArchives of Disease in Childhood
Volume87
Issue number3
DOIs
StatePublished - Sep 2002

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