Lactate dehydrogenase isoenzyme patterns in serum of patients with metastatic liver disease

Z. Rotenberg, I. Weinberger, E. Davidson, J. Fuchs, D. Harell, J. Agmon

Research output: Contribution to journalArticlepeer-review

Abstract

Total lactate dehydrogenase (LD, EC 1.1.1.27) and LD isoenzymes were determined in serum of 170 patients with metastatic liver disease, 35 of whom had multiple metastatic sites. Overall, values of LD were above normal for 78% of the 170 patients. Half of the patients had an isomorphic pattern of LD isoenzymes (i.e., relative increase in all five isoenzymes); the other half had an increased LD-4,5 pattern, mostly a solitary increase in LD-5 only. Of those patients with normal LD values, 92% had the increased LD-4,5 pattern, whereas 70% of patients with LD values > 350 U/L had an isomorphic pattern of LD isoenzymes. All 35 patients with multiple metastatic sites had LD activity > 350 U/L; in the majority of them (74%) it was > 500 U/L; in 31 (89%), the increase was isomorphic. The diagnostic efficiency of the combined LD > 225 U/L (upper limit of normal) and increased LD-4,5 test was much better than that of LD > 225 U/L alone (93% vs 74%). We conclude that serum LD and LD isoenzymes should be determined in every patient with suspected liver metastatic disease. The isomorphic pattern of LD isoenzymes is apparently associated with higher values for total LD and was common among the patients with multiple metastatic sites.

Original languageEnglish
Pages (from-to)871-873
Number of pages3
JournalClinical Chemistry
Volume35
Issue number5
DOIs
StatePublished - 1989
Externally publishedYes

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