Lack of suppressor T cells in renal transplant recipients and activation by aminophylline

B. Shohat, Z. Shapira, H. Joshua, C. Servadio

Research output: Contribution to journalArticlepeer-review


Immunoregulatory T-cell subsets were determined in 16 patients after renal transplantation. Suppressor and helper T lymphocytes were isolated with the aid of theophylline according to be method described by Shore et al. The system model used for assessing the function of these subsets was the local xenogeneic graft-versus-host reaction (GVHR). Lack of suppressor T cells was found in 6 out of the 16 patients, all 6 in acute steroid nonresponsive rejection crisis. Four of these patients received aminophylline per os at a dose of 1000 mg/kg per day and the T-lymphocyte subsets were retested several days afterwards. Active suppressor T cells (TS) appeared in all 4 treated patients, paralleled by disappearance of rejection crisis and a dramatic decrease of serum creatinine levels. These findings suggest that the inactivation of the immunoregulatory suppressor subset, probably by the immunosuppressive treatment, may play an important role in acute rejection and that activation of this subset of T suppressors could be of beneficial effect and prevent renal rejection.

Original languageEnglish
Pages (from-to)67-77
Number of pages11
Issue number2
StatePublished - 1983
Externally publishedYes


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