TY - JOUR
T1 - Lack of proliferation to alloantigen in a sibling of two infants with severe combined immunodeficiency (SCID)
AU - Spirer, Z.
AU - Zakuth, V.
AU - Tzechoval, E.
AU - Diamant, S.
AU - Segal, S.
PY - 1982/8
Y1 - 1982/8
N2 - A 6-year-old female sister of two infants who died from complications caused by severe combined immunodeficiency (SCID), is reported. Although clinically asymptomatic, she showed the following laboratory immunological abnormalities: negative MLC response, decreased number of E-rosettes, decreased response to PWM and Con A in spite of normal response to PHA, a high number of IgD-positive B cells, and normal immunoglobulin level. The importance of these findings is stressed and similar models are discussed as examples of complexity of the immune functions in animals and men.
AB - A 6-year-old female sister of two infants who died from complications caused by severe combined immunodeficiency (SCID), is reported. Although clinically asymptomatic, she showed the following laboratory immunological abnormalities: negative MLC response, decreased number of E-rosettes, decreased response to PWM and Con A in spite of normal response to PHA, a high number of IgD-positive B cells, and normal immunoglobulin level. The importance of these findings is stressed and similar models are discussed as examples of complexity of the immune functions in animals and men.
UR - https://www.scopus.com/pages/publications/0019973754
U2 - 10.1016/0090-1229(82)90239-2
DO - 10.1016/0090-1229(82)90239-2
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AN - SCOPUS:0019973754
SN - 0090-1229
VL - 24
SP - 286
EP - 291
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 2
ER -