Lack of proliferation to alloantigen in a sibling of two infants with severe combined immunodeficiency (SCID)

Z. Spirer, V. Zakuth, E. Tzechoval, S. Diamant, S. Segal

Research output: Contribution to journalArticlepeer-review

Abstract

A 6-year-old female sister of two infants who died from complications caused by severe combined immunodeficiency (SCID), is reported. Although clinically asymptomatic, she showed the following laboratory immunological abnormalities: negative MLC response, decreased number of E-rosettes, decreased response to PWM and Con A in spite of normal response to PHA, a high number of IgD-positive B cells, and normal immunoglobulin level. The importance of these findings is stressed and similar models are discussed as examples of complexity of the immune functions in animals and men.

Original languageEnglish
Pages (from-to)286-291
Number of pages6
JournalClinical Immunology and Immunopathology
Volume24
Issue number2
DOIs
StatePublished - Aug 1982

Fingerprint

Dive into the research topics of 'Lack of proliferation to alloantigen in a sibling of two infants with severe combined immunodeficiency (SCID)'. Together they form a unique fingerprint.

Cite this