Lack of modulatory effect of short-term repeated electroconvulsive therapy on platelet vesicular monoamine transporter 2 (VMAT2) in depressed patients

Avi Valevski*, Eran Pickholtz, Neta Roz, Abraham Weizman, Moshe Rehavi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the effect of electroconvulsive therapy (ECT) on platelet vesicular monoamine-transmitter-transporter 2 (pVMAT2) using high-affinity [3H]dihydrotetrabenazine binding to platelet VMAT2 in 11 women and 7 men, aged 53.7 ± 15.8. The Hamilton Depression Rating Scale (HAM-D) and the binding characteristic of pVMAT2 were assessed before and after six ECTs, administered over 21 days. A significant reduction (4.5 ± 0.46; 20.8%) was obtained in HAM-D scores (p < 0.01) following the ECTs. The pVMAT2 density (B max) and affinity values (K d) remained unaltered. Six ECTs are not sufficient for modulation in pVMAT2 expression. Long-term studies are needed to clarify the relationship between full remission and possible alterations in platelet/brain VMAT2 characteristics.

Original languageEnglish
Pages (from-to)881-885
Number of pages5
JournalJournal of Neural Transmission
Volume117
Issue number7
DOIs
StatePublished - Jul 2010

Keywords

  • Depression
  • Electroconvulsive therapy (ECT)
  • Serotoninergic system
  • Vesicular monoamine transporter 2 (VMAT2)

Fingerprint

Dive into the research topics of 'Lack of modulatory effect of short-term repeated electroconvulsive therapy on platelet vesicular monoamine transporter 2 (VMAT2) in depressed patients'. Together they form a unique fingerprint.

Cite this