TY - JOUR
T1 - Lack of MHC expression and retention of ultrastructural characteristics by xenograft transmissible venereal tumor cells in SCID mice
AU - Harmelin, A.
AU - Pinthus, J. H.
AU - Friedmann-Morvinski, D.
AU - Kaufman, K.
AU - Brenner, O.
PY - 2002
Y1 - 2002
N2 - Canine transmissible venereal tumor (CTVT) is primarily a tumor of adult dogs with a high incidence of spontaneous regression. We recently reported a xenograft model of CTVT (XTVT) in NOD/SCID mice. XTVT cells retain cytological and histological features of CTVT as well as characteristic rearranged LINE/c-MYC junction [Am. J. Vet. Res. 62 (2001) 907]. In this paper, we demonstrate that XTVT cells maintain ultrastructural characteristics of CTVT and do not express MHC classes I and II molecules.
AB - Canine transmissible venereal tumor (CTVT) is primarily a tumor of adult dogs with a high incidence of spontaneous regression. We recently reported a xenograft model of CTVT (XTVT) in NOD/SCID mice. XTVT cells retain cytological and histological features of CTVT as well as characteristic rearranged LINE/c-MYC junction [Am. J. Vet. Res. 62 (2001) 907]. In this paper, we demonstrate that XTVT cells maintain ultrastructural characteristics of CTVT and do not express MHC classes I and II molecules.
KW - Anti-tumor immunity
KW - Canine transmissible venereal tumor
KW - Electron microscopy
KW - MHC
KW - SCID mouse model
UR - http://www.scopus.com/inward/record.url?scp=0036236236&partnerID=8YFLogxK
U2 - 10.1016/S0165-2427(02)00036-3
DO - 10.1016/S0165-2427(02)00036-3
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AN - SCOPUS:0036236236
VL - 86
SP - 245
EP - 249
JO - Veterinary Immunology and Immunopathology
JF - Veterinary Immunology and Immunopathology
SN - 0165-2427
IS - 3-4
ER -