Lack of MHC expression and retention of ultrastructural characteristics by xenograft transmissible venereal tumor cells in SCID mice

A. Harmelin; J. H. Pinthus; D. Friedmann-Morvinski; K. Kaufman; O. Brenner

doi:10.1016/S0165-2427(02)00036-3

Lack of MHC expression and retention of ultrastructural characteristics by xenograft transmissible venereal tumor cells in SCID mice

A. Harmelin^*, J. H. Pinthus, D. Friedmann-Morvinski, K. Kaufman, O. Brenner

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Canine transmissible venereal tumor (CTVT) is primarily a tumor of adult dogs with a high incidence of spontaneous regression. We recently reported a xenograft model of CTVT (XTVT) in NOD/SCID mice. XTVT cells retain cytological and histological features of CTVT as well as characteristic rearranged LINE/c-MYC junction [Am. J. Vet. Res. 62 (2001) 907]. In this paper, we demonstrate that XTVT cells maintain ultrastructural characteristics of CTVT and do not express MHC classes I and II molecules.

Original language	English
Pages (from-to)	245-249
Number of pages	5
Journal	Veterinary Immunology and Immunopathology
Volume	86
Issue number	3-4
DOIs	https://doi.org/10.1016/S0165-2427(02)00036-3
State	Published - 2002
Externally published	Yes

Keywords

Anti-tumor immunity
Canine transmissible venereal tumor
Electron microscopy
MHC
SCID mouse model

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0165-2427(02)00036-3

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title = "Lack of MHC expression and retention of ultrastructural characteristics by xenograft transmissible venereal tumor cells in SCID mice",

abstract = "Canine transmissible venereal tumor (CTVT) is primarily a tumor of adult dogs with a high incidence of spontaneous regression. We recently reported a xenograft model of CTVT (XTVT) in NOD/SCID mice. XTVT cells retain cytological and histological features of CTVT as well as characteristic rearranged LINE/c-MYC junction [Am. J. Vet. Res. 62 (2001) 907]. In this paper, we demonstrate that XTVT cells maintain ultrastructural characteristics of CTVT and do not express MHC classes I and II molecules.",

keywords = "Anti-tumor immunity, Canine transmissible venereal tumor, Electron microscopy, MHC, SCID mouse model",

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T1 - Lack of MHC expression and retention of ultrastructural characteristics by xenograft transmissible venereal tumor cells in SCID mice

AU - Harmelin, A.

AU - Pinthus, J. H.

AU - Friedmann-Morvinski, D.

AU - Kaufman, K.

AU - Brenner, O.

PY - 2002

Y1 - 2002

N2 - Canine transmissible venereal tumor (CTVT) is primarily a tumor of adult dogs with a high incidence of spontaneous regression. We recently reported a xenograft model of CTVT (XTVT) in NOD/SCID mice. XTVT cells retain cytological and histological features of CTVT as well as characteristic rearranged LINE/c-MYC junction [Am. J. Vet. Res. 62 (2001) 907]. In this paper, we demonstrate that XTVT cells maintain ultrastructural characteristics of CTVT and do not express MHC classes I and II molecules.

AB - Canine transmissible venereal tumor (CTVT) is primarily a tumor of adult dogs with a high incidence of spontaneous regression. We recently reported a xenograft model of CTVT (XTVT) in NOD/SCID mice. XTVT cells retain cytological and histological features of CTVT as well as characteristic rearranged LINE/c-MYC junction [Am. J. Vet. Res. 62 (2001) 907]. In this paper, we demonstrate that XTVT cells maintain ultrastructural characteristics of CTVT and do not express MHC classes I and II molecules.

KW - Anti-tumor immunity

KW - Canine transmissible venereal tumor

KW - Electron microscopy

KW - MHC

KW - SCID mouse model

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AN - SCOPUS:0036236236

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VL - 86

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EP - 249

JO - Veterinary Immunology and Immunopathology

JF - Veterinary Immunology and Immunopathology

IS - 3-4

ER -

Lack of MHC expression and retention of ultrastructural characteristics by xenograft transmissible venereal tumor cells in SCID mice

Abstract

Keywords

UN SDGs

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