Lack of MHC expression and retention of ultrastructural characteristics by xenograft transmissible venereal tumor cells in SCID mice

A. Harmelin, J. H. Pinthus, D. Friedmann-Morvinski, K. Kaufman, O. Brenner

Research output: Contribution to journalArticlepeer-review

Abstract

Canine transmissible venereal tumor (CTVT) is primarily a tumor of adult dogs with a high incidence of spontaneous regression. We recently reported a xenograft model of CTVT (XTVT) in NOD/SCID mice. XTVT cells retain cytological and histological features of CTVT as well as characteristic rearranged LINE/c-MYC junction [Am. J. Vet. Res. 62 (2001) 907]. In this paper, we demonstrate that XTVT cells maintain ultrastructural characteristics of CTVT and do not express MHC classes I and II molecules.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalVeterinary Immunology and Immunopathology
Volume86
Issue number3-4
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Anti-tumor immunity
  • Canine transmissible venereal tumor
  • Electron microscopy
  • MHC
  • SCID mouse model

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