Lack of HER-2/neu expression in Hodgkin and non-Hodgkin lymphoma: An immunohistochemical study

Osnat Bairey*, Idit Pazgal, Elimelech Okon, Matityahu Shaklai, Sarah Morgenshtern

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. - Overexpression of HER-2/neu oncoprotein, a tyrosine kinase receptor, occurs in a variety of human cancers and has been shown to play a critical role in their development. This overexpression is usually associated with poor clinical outcome. The significance of HER-2/neu in lymphomas is unknown. The aim of this study was to evaluate the expression of HER-2/neu in the malignant lymphomas: non-Hodgkin and Hodgkin lymphomas. Methods. - We studied formalin-fixed, paraffin-embedded tissue from 50 patients with lymphoma. Forty-two specimens were from patients with various types of non-Hodgkin lymphoma, and 8 were from patients with Hodgkin lymphoma. HER-2/neu expression was examined by ah an immunohistochemical technique using the Hercep Test. Results. - None of the specimens demonstrated overexpression or even any expression of HER-2/neu. Reactive plasma cells showed cytoplasmic staining, which was not found in malignant plasma cells from patients with multiple myeloma. Conclusions. - Non-Hodgkin and Hodgkin lymphomas do not express the HER-2/neu oncoprotein. This finding suggests that HER-2/neu does not play a role in these diseases.

Original languageEnglish
Pages (from-to)574-576
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume126
Issue number5
StatePublished - 2002
Externally publishedYes

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