Lack of evidence for an association between two genetic polymorphisms in the tumor necrosis factor receptor 1 gene and multiple sclerosis in Ashkenazi Jews

Elon Pras, I. Aksentijevich, Y. Shinar, D. L. Kastner, A. Achiron

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple sclerosis (MS) is a multifactorial disease with a documented genetic component. Recent experimental models suggested a role for the tumor necrosis factor receptor 1 (TNFR1) in the pathogenesis of the disease. We compared the frequency of two polymorphisms from TNFR1, located in exon 1 and intron 6, in 94 Jewish Ashkenazi MS patients and 83 healthy Ashkenazi controls. No significant differences were observed for both polymorphisms between the patients and the controls. These findings suggest that genetic variants in TNFR1 do not play a significant role in Ashkenazi Jews.

Original languageEnglish
Pages (from-to)153-155
Number of pages3
JournalEuropean Neurology
Volume46
Issue number3
DOIs
StatePublished - 2001

Keywords

  • Ashkenazi association
  • Multiple sclerosis
  • Polymorphism
  • TNFR1

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