Lack of evidence for a major gene in the mendelian transmission of BMI in Chinese

Peng Yuan Liu; Yu Mei Li; Miao Xin Li; Ida Malkin; Yue Juan Qin; Xiang Ding Chen; Yong Jun Liu; Hong Wen Deng

doi:10.1038/oby.2004.247

Lack of evidence for a major gene in the mendelian transmission of BMI in Chinese

Peng Yuan Liu, Yu Mei Li, Miao Xin Li, Ida Malkin, Yue Juan Qin, Xiang Ding Chen, Yong Jun Liu, Hong Wen Deng^*

^*Corresponding author for this work

Anatomy and Anthropology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Objectives: To determine the heritability of BMI and to examine the mode of inheritance of BMI variation in Chinese. Research Methods and Procedures: Familial correlation and complex segregation analyses for BMI were undertaken in a Chinese sample composed of 392 nuclear families, with 1190 total individuals. Results: A moderate heritability was found for BMI (h² = 0.419-0.492). The obtained results do not support a ajor gene for BMI in our samples. BMI may be inherited in a complex and non-Mendelian manner in Chinese. Discussion: The findings of this study suggest that identification of specific genes for BMI in Chinese, at least within the same data set, is a serious challenge because of the lack of evidence of a major gene for BMI in our Chinese sample.

Original language	English
Pages (from-to)	1967-1973
Number of pages	7
Journal	Obesity Research
Volume	12
Issue number	12
DOIs	https://doi.org/10.1038/oby.2004.247
State	Published - Dec 2004

Funding

Funders	Funder number
National Institute of General Medical Sciences	R01GM060402
National Institute of Arthritis and Musculoskeletal and Skin Diseases	K01AR002170

Keywords

BMI
Chinese population
Familial correlation
Major genes
Segregation analysis

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10.1038/oby.2004.247

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title = "Lack of evidence for a major gene in the mendelian transmission of BMI in Chinese",

abstract = "Objectives: To determine the heritability of BMI and to examine the mode of inheritance of BMI variation in Chinese. Research Methods and Procedures: Familial correlation and complex segregation analyses for BMI were undertaken in a Chinese sample composed of 392 nuclear families, with 1190 total individuals. Results: A moderate heritability was found for BMI (h2 = 0.419-0.492). The obtained results do not support a ajor gene for BMI in our samples. BMI may be inherited in a complex and non-Mendelian manner in Chinese. Discussion: The findings of this study suggest that identification of specific genes for BMI in Chinese, at least within the same data set, is a serious challenge because of the lack of evidence of a major gene for BMI in our Chinese sample.",

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author = "Liu, {Peng Yuan} and Li, {Yu Mei} and Li, {Miao Xin} and Ida Malkin and Qin, {Yue Juan} and Chen, {Xiang Ding} and Liu, {Yong Jun} and Deng, {Hong Wen}",

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AU - Liu, Peng Yuan

AU - Li, Yu Mei

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AU - Malkin, Ida

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AU - Chen, Xiang Ding

AU - Liu, Yong Jun

AU - Deng, Hong Wen

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AB - Objectives: To determine the heritability of BMI and to examine the mode of inheritance of BMI variation in Chinese. Research Methods and Procedures: Familial correlation and complex segregation analyses for BMI were undertaken in a Chinese sample composed of 392 nuclear families, with 1190 total individuals. Results: A moderate heritability was found for BMI (h2 = 0.419-0.492). The obtained results do not support a ajor gene for BMI in our samples. BMI may be inherited in a complex and non-Mendelian manner in Chinese. Discussion: The findings of this study suggest that identification of specific genes for BMI in Chinese, at least within the same data set, is a serious challenge because of the lack of evidence of a major gene for BMI in our Chinese sample.

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Lack of evidence for a major gene in the mendelian transmission of BMI in Chinese

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Keywords

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