Lack of effect of methylphenidate on serum growth hormone (GH), GH- binding protein, and insulin-like growth factor I

Paz Toren, Aviva Silbergeld, Sofia Eldar, Nathaniel Laor, Leo Wolmer, Sharon Koren, Raphael Weitz, Dov Inbar, Ahuva Reiss, Rina Eshet, Ronit Weizman

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to assess the growth hormone (GH) axis in methylphenidate (MPH)-treated and untreated boys with attention-deficit and hyperactivity disorder (ADHD), by evaluating serum GH, GH-binding protein (GHBP) activity, and insulin-like growth factor I (IGF-I) levels as compared to age-matched normal controls. Blood samples were taken from 42 boys (aged 6-16 years) diagnosed as having ADHD according to DSM-III-R criteria and confirmed by using the Schedule for Affective Disorder and Schizophrenia for school-age children (K[Kiddle]-SADS). A total of 21 patients were treated with MPH (520 mg/day; 0.15-0.77 mg/kg/day), on a drug holiday protocol, for 1-36 months, and 21 were drug naive. A total of 46 age-matched normal boys at height and weight within normal range served as controls. No significant differences were detected between the MPH-treated ADHD children, the untreated ADHD children, and the control children on fasting serum GH levels, GHBP activity, or IGF-I levels. Active treatment with MPH, in ADHD children on a drug holiday protocol, does not cause changes in GH axis as manifested by normal values of GH, GHBP, and IGF-I.

Original languageEnglish
Pages (from-to)264-269
Number of pages6
JournalClinical Neuropharmacology
Volume20
Issue number3
DOIs
StatePublished - 1997

Keywords

  • Attention deficit and hyperactivity disorder
  • Growth hormone
  • Growth hormone-binding protein
  • Insulin-like growth factor I
  • Methylphenidate

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