Lack of effect of cannabinoids on carbonic anhydrase

Dalia Maor*, Therese Treves, A. D. Korczyn

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Cannabinoids have significant anticonvulsant effects, the mechanism of which is obscure. In addition, these agents reduce intraocular pressure. Inhibitors of carbonic anhydrase also share these two pharmacological actions. In order to investigate whether these actions of Cannabinoids are mediated through inhibition of carbonic anhydrase (CA), commercial solutions of the enzyme were exposed to Δ9-tetrahydrocannabinol and cannabidiol. No inhibition was observed at concentrations of 10-7-10-6 M.

Original languageEnglish
Pages (from-to)205-206
Number of pages2
JournalJournal of Neural Transmission
Issue number3
StatePublished - Sep 1980


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