Lack of effect of 28 days of neuroleptic treatment on platelet benzodiazepine binding sites in schizophrenics

Zehava Tanne, Ronit Weizman, Leon Karp, Yeshayahu Katz, Sam Tyano, Moshe Gavish*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty-eight days of neuroleptic treatment of 11 schizophrenics aged 16-23 years did not affect the binding values of 3H-PK. 11195 to platelets. This lack of effect was in contrast to reduced peripheral benzodiazepine binding sites (PBS) observed in platelets of schizophrenics medicated over 2 years. These results may indicate that ncurolcptic-induccd down-rcgulation of PBS is a time-dependent phenomenon.

Original languageEnglish
Pages (from-to)121-123
Number of pages3
JournalNeuropsychobiology
Volume17
Issue number3
DOIs
StatePublished - 1987

Keywords

  • Benzodiazepine receptors
  • Neuroleptics
  • Peripheral benzodiazepine binding sites
  • Schizophrenia

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