Twenty-eight days of neuroleptic treatment of 11 schizophrenics aged 16-23 years did not affect the binding values of 3H-PK. 11195 to platelets. This lack of effect was in contrast to reduced peripheral benzodiazepine binding sites (PBS) observed in platelets of schizophrenics medicated over 2 years. These results may indicate that ncurolcptic-induccd down-rcgulation of PBS is a time-dependent phenomenon.
- Benzodiazepine receptors
- Peripheral benzodiazepine binding sites