Lack of apolipoprotein-E exacerbates experimental allergic encephalomyelitis

Dimitrios Karussis; D. M. Michaelson; N. Grigoriadis; A. D. Korezyn; R. Mizrachi-Koll; S. Chapman; O. Abramsky; J. Chapman

doi:10.1191/1352458503ms950oa

Lack of apolipoprotein-E exacerbates experimental allergic encephalomyelitis

Dimitrios Karussis^*, D. M. Michaelson, N. Grigoriadis, A. D. Korezyn, R. Mizrachi-Koll, S. Chapman, O. Abramsky, J. Chapman

^*Corresponding author for this work

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Abstract

Experimental autoimmune encephalomyelitis (EAE) was found to have a chronic and significantly worse course in apolipoprotein-E (apoE) deficient female mice when compared with matched controls. Disease measures compared included incidence of EAE (64% versus 31%, P<0.05, χ² test), maximal clinical score (average±SD 2.81±2.5 versus 0.75±1.1, P<0.01, Mann-Whitney test) and mortality (27.3% versus 0%, P = 0.02, Mann-Whitney test and χ² test). ApoE deficient mice had significantly increased lymphocyte proliferation responses to both myelin antigens and mitogens and significantly more infiltrating lesions in the central nervous system (CNS) in histopathology. Defective neuronal repair mechanisms and enhanced immune reactivity in apoE deficient mice may explain our findings. Clinical implications for MS are discussed.

Original language	English
Pages (from-to)	476-480
Number of pages	5
Journal	Multiple Sclerosis Journal
Volume	9
Issue number	5
DOIs	https://doi.org/10.1191/1352458503ms950oa
State	Published - Oct 2003

Keywords

Alzheimer's disease
ApoE
Experimental autoimmune encephalomyelitis (EAE)
Multiple schlerosis

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title = "Lack of apolipoprotein-E exacerbates experimental allergic encephalomyelitis",

abstract = "Experimental autoimmune encephalomyelitis (EAE) was found to have a chronic and significantly worse course in apolipoprotein-E (apoE) deficient female mice when compared with matched controls. Disease measures compared included incidence of EAE (64% versus 31%, P<0.05, χ2 test), maximal clinical score (average±SD 2.81±2.5 versus 0.75±1.1, P<0.01, Mann-Whitney test) and mortality (27.3% versus 0%, P = 0.02, Mann-Whitney test and χ2 test). ApoE deficient mice had significantly increased lymphocyte proliferation responses to both myelin antigens and mitogens and significantly more infiltrating lesions in the central nervous system (CNS) in histopathology. Defective neuronal repair mechanisms and enhanced immune reactivity in apoE deficient mice may explain our findings. Clinical implications for MS are discussed.",

keywords = "Alzheimer's disease, ApoE, Experimental autoimmune encephalomyelitis (EAE), Multiple schlerosis",

author = "Dimitrios Karussis and Michaelson, {D. M.} and N. Grigoriadis and Korezyn, {A. D.} and R. Mizrachi-Koll and S. Chapman and O. Abramsky and J. Chapman",

year = "2003",

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AU - Karussis, Dimitrios

AU - Michaelson, D. M.

AU - Grigoriadis, N.

AU - Korezyn, A. D.

AU - Mizrachi-Koll, R.

AU - Chapman, S.

AU - Abramsky, O.

AU - Chapman, J.

PY - 2003/10

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N2 - Experimental autoimmune encephalomyelitis (EAE) was found to have a chronic and significantly worse course in apolipoprotein-E (apoE) deficient female mice when compared with matched controls. Disease measures compared included incidence of EAE (64% versus 31%, P<0.05, χ2 test), maximal clinical score (average±SD 2.81±2.5 versus 0.75±1.1, P<0.01, Mann-Whitney test) and mortality (27.3% versus 0%, P = 0.02, Mann-Whitney test and χ2 test). ApoE deficient mice had significantly increased lymphocyte proliferation responses to both myelin antigens and mitogens and significantly more infiltrating lesions in the central nervous system (CNS) in histopathology. Defective neuronal repair mechanisms and enhanced immune reactivity in apoE deficient mice may explain our findings. Clinical implications for MS are discussed.

AB - Experimental autoimmune encephalomyelitis (EAE) was found to have a chronic and significantly worse course in apolipoprotein-E (apoE) deficient female mice when compared with matched controls. Disease measures compared included incidence of EAE (64% versus 31%, P<0.05, χ2 test), maximal clinical score (average±SD 2.81±2.5 versus 0.75±1.1, P<0.01, Mann-Whitney test) and mortality (27.3% versus 0%, P = 0.02, Mann-Whitney test and χ2 test). ApoE deficient mice had significantly increased lymphocyte proliferation responses to both myelin antigens and mitogens and significantly more infiltrating lesions in the central nervous system (CNS) in histopathology. Defective neuronal repair mechanisms and enhanced immune reactivity in apoE deficient mice may explain our findings. Clinical implications for MS are discussed.

KW - Alzheimer's disease

KW - ApoE

KW - Experimental autoimmune encephalomyelitis (EAE)

KW - Multiple schlerosis

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Lack of apolipoprotein-E exacerbates experimental allergic encephalomyelitis

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Keywords

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