Laboratory assessment and diagnosis of congenital viral infections: Rubella, cytomegalovirus (CMV), varicella-zoster virus (VZV), herpes simplex virus (HSV), parvovirus B19 and human immunodeficiency virus (HIV)

Ella Mendelson, Yair Aboudy, Zahava Smetana, Michal Tepperberg, Zahava Grossman

Research output: Contribution to journalReview articlepeer-review

Abstract

Viral infections during pregnancy may cause fetal or neonatal damage. Clinical intervention, which is required for certain viral infections, relies on laboratory tests performed during pregnancy and at the neonatal stage. This review describes traditional and advanced laboratory approaches and testing methods used for assessment of the six most significant viral infections during pregnancy: rubella virus (RV), cytomegalovirus (CMV), varicella-zoster virus (VZV), herpes simplex virus (HSV), parvovirus B19 and human immunodeficiency virus (HIV). Interpretation of the laboratory tests results according to studies published in recent years is discussed.

Original languageEnglish
Pages (from-to)350-382
Number of pages33
JournalReproductive Toxicology
Volume21
Issue number4
DOIs
StatePublished - May 2006
Externally publishedYes

Keywords

  • Congenital viral infections
  • Cytomegalovirus (CMV)
  • Herpes simplex virus (HSV)
  • Human immunodeficiency virus (HIV)
  • Laboratory diagnosis
  • Parvovirus B19
  • Rubella
  • Varicella-zoster virus (VZV)

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