TY - JOUR
T1 - Laboratory and free-living gait performance in adults with COPD and healthy controls
AU - Buekers, Joren
AU - Megaritis, Dimitrios
AU - Koch, Sarah
AU - Alcock, Lisa
AU - Ammour, Nadir
AU - Becker, Clemens
AU - Bertuletti, Stefano
AU - Bonci, Tecla
AU - Brown, Philip
AU - Buckley, Ellen
AU - Buttery, Sara C.
AU - Caulfied, Brian
AU - Cereatti, Andrea
AU - Chynkiamis, Nikolaos
AU - Demeyer, Heleen
AU - Echevarria, Carlos
AU - Frei, Anja
AU - Hansen, Clint
AU - Hausdorff, Jeffrey M.
AU - Hopkinson, Nicholas S.
AU - Hume, Emily
AU - Kuederle, Arne
AU - Maetzler, Walter
AU - Mazzà, Claudia
AU - Micó-Amigo, Encarna M.
AU - Mueller, Arne
AU - Palmerini, Luca
AU - Salis, Francesca
AU - Scott, Kirsty
AU - Troosters, Thierry
AU - Vereijken, Beatrix
AU - Watz, Henrik
AU - Rochester, Lynn
AU - Din, Silvia Del
AU - Vogiatzis, Ioannis
AU - Garcia-Aymerich, Judith
N1 - Publisher Copyright:
© The authors 2023.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Background Gait characteristics are important risk factors for falls, hospitalisations and mortality in older adults, but the impact of COPD on gait performance remains unclear. We aimed to identify differences in gait characteristics between adults with COPD and healthy age-matched controls during 1) laboratory tests that included complex movements and obstacles, 2) simulated daily-life activities (supervised) and 3) free-living daily-life activities (unsupervised). Methods This case–control study used a multi-sensor wearable system (INDIP) to obtain seven gait characteristics for each walking bout performed by adults with mild-to-severe COPD (n=17; forced expiratory volume in 1 s 57±19% predicted) and controls (n=20) during laboratory tests, and during simulated and free-living daily-life activities. Gait characteristics were compared between adults with COPD and healthy controls for all walking bouts combined, and for shorter (⩽30 s) and longer (>30 s) walking bouts separately. Results Slower walking speed (−11 cm·s−1, 95% CI: −20 to −3) and lower cadence (−6.6 steps·min−1, 95% CI: −12.3 to −0.9) were recorded in adults with COPD compared to healthy controls during longer (>30 s) free-living walking bouts, but not during shorter (⩽30 s) walking bouts in either laboratory or free-living settings. Double support duration and gait variability measures were generally comparable between the two groups. Conclusion Gait impairment of adults with mild-to-severe COPD mainly manifests during relatively long walking bouts (>30 s) in free-living conditions. Future research should determine the underlying mechanism(s) of this impairment to facilitate the development of interventions that can improve free-living gait performance in adults with COPD.
AB - Background Gait characteristics are important risk factors for falls, hospitalisations and mortality in older adults, but the impact of COPD on gait performance remains unclear. We aimed to identify differences in gait characteristics between adults with COPD and healthy age-matched controls during 1) laboratory tests that included complex movements and obstacles, 2) simulated daily-life activities (supervised) and 3) free-living daily-life activities (unsupervised). Methods This case–control study used a multi-sensor wearable system (INDIP) to obtain seven gait characteristics for each walking bout performed by adults with mild-to-severe COPD (n=17; forced expiratory volume in 1 s 57±19% predicted) and controls (n=20) during laboratory tests, and during simulated and free-living daily-life activities. Gait characteristics were compared between adults with COPD and healthy controls for all walking bouts combined, and for shorter (⩽30 s) and longer (>30 s) walking bouts separately. Results Slower walking speed (−11 cm·s−1, 95% CI: −20 to −3) and lower cadence (−6.6 steps·min−1, 95% CI: −12.3 to −0.9) were recorded in adults with COPD compared to healthy controls during longer (>30 s) free-living walking bouts, but not during shorter (⩽30 s) walking bouts in either laboratory or free-living settings. Double support duration and gait variability measures were generally comparable between the two groups. Conclusion Gait impairment of adults with mild-to-severe COPD mainly manifests during relatively long walking bouts (>30 s) in free-living conditions. Future research should determine the underlying mechanism(s) of this impairment to facilitate the development of interventions that can improve free-living gait performance in adults with COPD.
UR - http://www.scopus.com/inward/record.url?scp=85173016255&partnerID=8YFLogxK
U2 - 10.1183/23120541.00159-2023
DO - 10.1183/23120541.00159-2023
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C2 - 37753279
AN - SCOPUS:85173016255
SN - 2312-0541
VL - 9
JO - ERJ Open Research
JF - ERJ Open Research
IS - 5
M1 - 00159-2023
ER -