l-DOPA's mechanism of action in Parkinson's disease

Franz Hefti, Eldad Melamed

Research output: Contribution to journalArticlepeer-review


Despite the long clinical use of l-DOPA, the exact mechanism by which this drug alleviates symptoms of Parkinson's disease is far from being fully understood. The present review summarizes recent findings about the mechanism of action of l-DOPA. Special emphasis is given to the most important phenomenon that limits l-DOPA's use in the treatment of parkinsonism -its declining effectiveness.

Original languageEnglish
Pages (from-to)229-231
Number of pages3
JournalTrends in Neurosciences
Issue number10
StatePublished - 1980
Externally publishedYes


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