l-Alanine:4,5-dioxovalerate transaminase does not regulate heme synthesis in rat liver

Rivka Mamet; Rachel Mevasser; Yonit Bomstein; Abraham Atsmon; Nili Schoenfeld

doi:10.1016/0304-4165(90)90068-8

l-Alanine:4,5-dioxovalerate transaminase does not regulate heme synthesis in rat liver

Rivka Mamet, Rachel Mevasser, Yonit Bomstein, Abraham Atsmon, Nili Schoenfeld^*

^*Corresponding author for this work

Clinical Departments

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

l-Alanine:4,5-dioxovalerate transaminase (ADT) was determined in liver homogenates of rats treated by either inducers of porphyrin synthesis or the repressor, hemin. ADT activity was not induced by the porphyrinogenic agents nor reduced by hemin, indicating that ADT probably has no regulatory role in the heme synthesis pathway. The same conclusion was drawn from similar experiments performed in monolayers of chick embryo liver cells.

Original language	English
Pages (from-to)	148-151
Number of pages	4
Journal	Biochimica et Biophysica Acta - General Subjects
Volume	1034
Issue number	2
DOIs	https://doi.org/10.1016/0304-4165(90)90068-8
State	Published - 16 May 1990

Keywords

Alanine
Dioxovalerate transaminase
Heme synthesis
Regulation

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10.1016/0304-4165(90)90068-8

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title = "l-Alanine:4,5-dioxovalerate transaminase does not regulate heme synthesis in rat liver",

abstract = "l-Alanine:4,5-dioxovalerate transaminase (ADT) was determined in liver homogenates of rats treated by either inducers of porphyrin synthesis or the repressor, hemin. ADT activity was not induced by the porphyrinogenic agents nor reduced by hemin, indicating that ADT probably has no regulatory role in the heme synthesis pathway. The same conclusion was drawn from similar experiments performed in monolayers of chick embryo liver cells.",

keywords = "Alanine, Dioxovalerate transaminase, Heme synthesis, Regulation",

author = "Rivka Mamet and Rachel Mevasser and Yonit Bomstein and Abraham Atsmon and Nili Schoenfeld",

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T1 - l-Alanine:4,5-dioxovalerate transaminase does not regulate heme synthesis in rat liver

AU - Mamet, Rivka

AU - Mevasser, Rachel

AU - Bomstein, Yonit

AU - Atsmon, Abraham

AU - Schoenfeld, Nili

PY - 1990/5/16

Y1 - 1990/5/16

N2 - l-Alanine:4,5-dioxovalerate transaminase (ADT) was determined in liver homogenates of rats treated by either inducers of porphyrin synthesis or the repressor, hemin. ADT activity was not induced by the porphyrinogenic agents nor reduced by hemin, indicating that ADT probably has no regulatory role in the heme synthesis pathway. The same conclusion was drawn from similar experiments performed in monolayers of chick embryo liver cells.

AB - l-Alanine:4,5-dioxovalerate transaminase (ADT) was determined in liver homogenates of rats treated by either inducers of porphyrin synthesis or the repressor, hemin. ADT activity was not induced by the porphyrinogenic agents nor reduced by hemin, indicating that ADT probably has no regulatory role in the heme synthesis pathway. The same conclusion was drawn from similar experiments performed in monolayers of chick embryo liver cells.

KW - Alanine

KW - Dioxovalerate transaminase

KW - Heme synthesis

KW - Regulation

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JO - Biochimica et Biophysica Acta - General Subjects

JF - Biochimica et Biophysica Acta - General Subjects

IS - 2

ER -

l-Alanine:4,5-dioxovalerate transaminase does not regulate heme synthesis in rat liver

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Keywords

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