@article{4fc1632ee6ca489ea9ff9b688bd6f89d,
title = "KRAS Activating Signaling Triggers Arteriovenous Malformations",
abstract = "The underlying genetic causes and altered signaling pathways of brain arteriovenous malformations remain unknown. A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)–ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells.",
keywords = "KRAS, KRAS4A, brain arteriovenous malformations, endothelial cells, somatic mutation",
author = "Feixiong Cheng and Ruth Nussinov",
note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2018",
month = jul,
doi = "10.1016/j.tibs.2018.04.007",
language = "אנגלית",
volume = "43",
pages = "481--483",
journal = "Trends in Biochemical Sciences",
issn = "0968-0004",
publisher = "Elsevier Ltd.",
number = "7",
}