KRAS Activating Signaling Triggers Arteriovenous Malformations

Feixiong Cheng*, Ruth Nussinov

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

13 Scopus citations

Abstract

The underlying genetic causes and altered signaling pathways of brain arteriovenous malformations remain unknown. A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)–ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells.

Original languageEnglish
Pages (from-to)481-483
Number of pages3
JournalTrends in Biochemical Sciences
Volume43
Issue number7
DOIs
StatePublished - Jul 2018

Funding

FundersFunder number
National Institutes of HealthHHSN261200800001E
National Heart, Lung, and Blood InstituteK99HL138272
National Cancer InstituteZIABC010442
Frederick National Laboratory for Cancer Research

    Keywords

    • KRAS
    • KRAS4A
    • brain arteriovenous malformations
    • endothelial cells
    • somatic mutation

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