KRAS Activating Signaling Triggers Arteriovenous Malformations

Feixiong Cheng*, Ruth Nussinov

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review


The underlying genetic causes and altered signaling pathways of brain arteriovenous malformations remain unknown. A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)–ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells.

Original languageEnglish
Pages (from-to)481-483
Number of pages3
JournalTrends in Biochemical Sciences
Issue number7
StatePublished - Jul 2018


  • KRAS
  • KRAS4A
  • brain arteriovenous malformations
  • endothelial cells
  • somatic mutation


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