KRAS Activating Signaling Triggers Arteriovenous Malformations

Feixiong Cheng; Ruth Nussinov

doi:10.1016/j.tibs.2018.04.007

KRAS Activating Signaling Triggers Arteriovenous Malformations

Feixiong Cheng^*, Ruth Nussinov

^*Corresponding author for this work

Human Molecular Genetics Biochemistry

Research output: Contribution to journal › Letter › peer-review

Abstract

The underlying genetic causes and altered signaling pathways of brain arteriovenous malformations remain unknown. A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)–ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells.

Original language	English
Pages (from-to)	481-483
Number of pages	3
Journal	Trends in Biochemical Sciences
Volume	43
Issue number	7
DOIs	https://doi.org/10.1016/j.tibs.2018.04.007
State	Published - Jul 2018

Keywords

KRAS
KRAS4A
brain arteriovenous malformations
endothelial cells
somatic mutation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tibs.2018.04.007

Cite this

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title = "KRAS Activating Signaling Triggers Arteriovenous Malformations",

abstract = "The underlying genetic causes and altered signaling pathways of brain arteriovenous malformations remain unknown. A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)–ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells.",

keywords = "KRAS, KRAS4A, brain arteriovenous malformations, endothelial cells, somatic mutation",

author = "Feixiong Cheng and Ruth Nussinov",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

month = jul,

doi = "10.1016/j.tibs.2018.04.007",

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AU - Cheng, Feixiong

AU - Nussinov, Ruth

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AB - The underlying genetic causes and altered signaling pathways of brain arteriovenous malformations remain unknown. A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)–ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells.

KW - KRAS

KW - KRAS4A

KW - brain arteriovenous malformations

KW - endothelial cells

KW - somatic mutation

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DO - 10.1016/j.tibs.2018.04.007

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.letter???

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JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 7

ER -

KRAS Activating Signaling Triggers Arteriovenous Malformations

Abstract

Keywords

UN SDGs

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