@article{65ed30f4f081465f9065c096528e3970,
title = "Kr{\"u}ppel-like factor 12 promotes colorectal cancer growth through early growth response protein 1",
abstract = "Kr{\"u}ppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in colorectal cancer (CRC). Indeed, KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC and could serve as a potential prognostic marker and therapeutic target.",
author = "Kim, {Sun Hee} and Park, {Yun Yong} and Cho, {Sung Nam} and Ofer Margalit and Dingzhi Wang and Dubois, {Raymond N.}",
note = "Publisher Copyright: {\textcopyright} 2016 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2016",
month = jul,
day = "1",
doi = "10.1371/journal.pone.0159899",
language = "אנגלית",
volume = "11",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",
}
