KPC-like carbapenemase-producing enterobacteriaceae colonizing patients in Europe and Israel

A. Baraniak, R. Izdebski, J. Fiett, M. Herda, L. P.G. Derde, M. J.M. Bonten, A. Adler, Y. Carmeli, H. Goossens, W. Hryniewicz, C. Brun-Buisson, M. Gniadkowski*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


In a 2008-2011 survey, 17,945 patients in 18 hospital units in Europe and Israel were screened for carriage of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae, resulting in identification of 124 positive patients. The isolates were dominated by Klebsiella pneumoniae sequence type 258 (ST258) KPC-2 and ST512 KPC-3, mainly from Greece and Italy, respectively, whereas Israeli isolates were of diverse species, clones, and KPC variants. Various blaKPC platforms were observed, among which IncFIIK-FIBK plasmids with blaKPC-2/-3 genes in the Tn4401a transposon prevailed.

Original languageEnglish
Pages (from-to)1912-1917
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Issue number3
StatePublished - Mar 2016
Externally publishedYes


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